Ferroptosis landscape in prostate cancer from molecular and metabolic perspective

被引：11

作者：

Liang, Jiaming ^{[1
]}

Liao, Yihao ^{[1
]}

Wang, Pu ^{[1
]}

Yang, Kun ^{[2
]}

Wang, Youzhi ^{[1
]}

Wang, Keke ^{[3
]}

Zhong, Boqiang ^{[1
]}

Zhou, Diansheng ^{[1
]}

Cao, Qian ^{[1
]}

Li, Junbo ^{[1
]}

Zhao, Yang ^{[4
]}

Jiang, Ning ^{[1
]}

机构：

[1] Tianjin Med Univ, Hosp 2, Tianjin Inst Urol, Tianjin 300211, Peoples R China

[2] Xi An Jiao Tong Univ, Sch Future Technol, Xian 710049, Shaanxi, Peoples R China

[3] Air Force Mil Med Univ, Tangdu Hosp, Dept Urol, Xian, Shaanxi, Peoples R China

[4] Tianjin Med Univ, Hosp 2, Dept Radiol, Tianjin, Peoples R China

来源：

CELL DEATH DISCOVERY | 2023年 / 9卷 / 01期

关键词：

AMINO-ACID TRANSPORTER; CASTRATION-RESISTANT; SELENIUM SUPPLEMENTATION; OXIDATIVE STRESS; VITAMIN-E; MESENCHYMAL TRANSITION; INHIBITS FERROPTOSIS; TRANSFERRIN RECEPTOR; LIPID-PEROXIDATION; IRON HOMEOSTASIS;

D O I：

10.1038/s41420-023-01430-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Prostate cancer is a major disease that threatens men's health. Its rapid progression, easy metastasis, and late castration resistance have brought obstacles to treatment. It is necessary to find new effective anticancer methods. Ferroptosis is a novel iron-dependent programmed cell death that plays a role in various cancers. Understanding how ferroptosis is regulated in prostate cancer will help us to use it as a new way to kill cancer cells. In this review, we summarize the regulation and role of ferroptosis in prostate cancer and the relationship with AR from the perspective of metabolism and molecular pathways. We also discuss the feasibility of ferroptosis in prostate cancer treatment and describe current limitations and prospects, providing a reference for future research and clinical application of ferroptosis.

引用

页数：12

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