Inflammatory Biomarkers in Elite Cross-Country Skiers After a Competition Season: A Case-Control Study

被引:5
|
作者
Luoto, Raakel [1 ,2 ]
Ruuskanen, Olli [1 ,2 ,7 ]
Ihalainen, Johanna K. [3 ]
Pekkala, Satu [3 ]
Hintikka, Jukka [3 ]
Kanerva, Noora [4 ]
Waris, Matti [5 ]
Heinonen, Olli J. [6 ]
Valtonen, Maarit [8 ]
机构
[1] Turku Univ Hosp, Dept Paediat & Adolescent Med, PL 52, Turku 20521, Finland
[2] Univ Turku, PL 52, Turku 20521, Finland
[3] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland
[4] Univ Helsinki, Dept Food & Nutr, Helsinki, Finland
[5] Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Clin Virol, Turku, Finland
[6] Univ Turku, Paavo Nurmi Ctr, Turku, Finland
[7] Univ Turku, Unit Hlth & Phys Act, Turku, Finland
[8] KIHU, Finnish Inst High Performance, 6 Rautpohjankatu, Jyvaskyla 40700, Finland
关键词
Athlete; Biomarker; Chronic low-grade inflammation; Exercise; GlycA; Inflammation; PHYSICAL-ACTIVITY; SKELETAL-MUSCLE; T-CELLS; EXERCISE; PREVENTION; MECHANISMS; RESPONSES;
D O I
10.1007/s42978-022-00186-w
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
PurposeWhether elite athletes, who have been exposed to vigorous-intensity exercise combined with other stressors, have elevated systemic low-grade inflammation, remains largely unclear. To address this question, we studied the levels of six inflammatory cytokines as potential biomarkers of a low-grade inflammatory state in elite athletes after an 11-month training and competition season.MethodsWe collected sera from 27 Finnish elite cross-country skiers and 27 gender- and age-matched, moderately-exercising controls. The serum concentrations of C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), glycoprotein acetyls (GlycA), interleukin 10 (IL-10), and interferon gamma (IFN-gamma) cytokines were quantified as surrogate markers of low-grade inflammation.ResultsThe athletes were found to have significantly lower concentrations of CRP (P = 0.0232) and higher concentrations of IL-10, TNF-alpha, and IFN-gamma (P = 0.0097, P = 0.0256, and P = 0.0185, respectively) than the controls. No significant differences between athletes and controls were detected in the concentrations of IL-6 and GlycA. The inflammatory score (IS) did not differ significantly between athletes and controls.ConclusionThe results of this study argued against the hypothesis of a significant chronic low-grade inflammation in response to prolonged high-performance exercise among elite endurance athletes.
引用
收藏
页码:254 / 262
页数:9
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