Sterically shielded pyrrolidine nitroxides with 3-(4,5-dicarboxy-1H-1,2,3-triazol-1-yl)propyl substituent

被引：1

作者：

Trakhinina, S. Yu. ^{[1
,2
]}

Taratayko, A. I. ^{[1
]}

Glazachev, Yu. I. ^{[3
]}

Kirilyuk, I. A. ^{[1
]}

机构：

[1] Russian Acad Sci, NN Vorozhtsov Inst Organ Chem, Siberian Branch, 9 Prosp Akad Lavrenteva, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, 1 Ul Pirogova, Novosibirsk 630090, Russia

[3] Russian Acad Sci, Siberian Branch, Voevodsky Inst Chem Kinet & Combust, 3 Ul Inst Skaya, Novosibirsk 630090, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 07期

基金：

俄罗斯科学基金会;

关键词：

nitrones; nitroxides; Grignard reagents; pyrrolidine; reduction kinetics;

D O I：

10.1007/s11172-023-3935-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water-soluble spin probes were obtained from reduction-resistant sterically shielded pyrrolidine nitroxides by forming a 4,5-dicarboxy-1H-1,2,3-triazole fragment in the side chain by the Huisgen reaction of the azido group with acetylenedicarboxylic acid ester followed by hydrolysis. For the synthesized radicals, the reduction rate constants by ascorbate and the partition coefficient in an octanol-water system were determined.

引用

页码：1569 / 1575

页数：7

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