One pot synthetic approach to 2-methyl-5-phenyl-7-amino-[1,3,4]-thiadiazolo[3,2-α]pyrimidine-6-carbonitrile derivatives with antifungal evaluation

被引：0

作者：

Saikia, Rimpi ^{[1
]}

Bharali, Jumi ^{[1
]}

Borthakur, Sukanya ^{[2
]}

Kalita, Pabitra Kumar ^{[3
]}

Sarma, Pradyut ^{[1
]}

Saikia, Prakash Jyoti ^{[4
]}

Dutta, Mintu Maan ^{[1
]}

Borthakur, Susanta Kumar ^{[1
,5
]}

机构：

[1] Arya Vidyapeeth Coll, Dept Chem, Gauhati, India

[2] Forens Sci Lab, Gauhati, India

[3] Sibsagar Coll, Dept Chem, Sivsagar, India

[4] CSIR NEIST, Mat Sci & Technol Div, Analyt Chem Grp, Jorhat, India

[5] Arya Vidyapeeth Coll, Dept Chem, PO Gopinath Nagar, Gauhati 781016, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2024年 / 61卷 / 05期

关键词：

D O I：

10.1002/jhet.4801

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel 2-methyl-5-phenyl-7-amino-[1,3,4]-thiadiazolo[3,2-alpha]pyrimidine-6-carbonitrile derivatives 3 were synthesized from 2-amino-5-methyl-1,3,4-thiadiazole 1 and benzylidinemalononitrile 2 in ethanol by refluxing the mixture with catalytic amount of NaOH. The structures of all compounds were characterized by elemental analysis, IR, MS, and 1H nuclear magnetic resonance spectra. The newly synthesized compounds were also seen as an affective fungicide against Rhizoctonia solani and Trichoderma sp., two fungal microbes causing diseases in rice plants.

引用

页码：771 / 777

页数：7

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