Neonatal mortality risk of vulnerable newborns: A descriptive analysis of subnational, population-based birth cohorts for 238 143 live births in low- and middle-income settings from 2000 to 2017

被引：5

作者：

Hazel, Elizabeth A. ^{[1
,6
]}

Erchick, Daniel J. ^{[1
]}

Katz, Joanne ^{[1
]}

Lee, Anne C. C. ^{[2
]}

Diaz, Michael ^{[1
]}

Wu, Lee S. F. ^{[1
]}

West Jr, Keith P. P. ^{[3
]}

Shamim, Abu Ahmed ^{[4
]}

Christian, Parul ^{[3
]}

Ali, Hasmot ^{[5
]}

Baqui, Abdullah H. ^{[6
]}

Saha, Samir K. ^{[7
]}

Ahmed, Salahuddin ^{[8
]}

Roy, Arunangshu Dutta ^{[8
]}

Silveira, Mariangela F. ^{[9
]}

Buffarini, Romina ^{[9
]}

Shapiro, Roger ^{[10
]}

Zash, Rebecca ^{[11
]}

Kolsteren, Patrick ^{[12
]}

Lachat, Carl

Huybregts, Lieven ^{[12
,13
]}

Roberfroid, Dominique ^{[14
,15
]}

Zhu, Zhonghai ^{[16
]}

Zeng, Lingxia ^{[16
]}

Gebreyesus, Seifu H. ^{[17
]}

Tesfamariam, Kokeb ^{[18
]}

Adu-Afarwuah, Seth ^{[19
]}

Dewey, Kathryn G. ^{[20
]}

Gyaase, Stephaney ^{[21
]}

Poku-Asante, Kwaku ^{[21
]}

Boamah Kaali, Ellen ^{[21
,22
]}

Jack, Darby ^{[23
]}

Ravilla, Thulasiraj ^{[24
]}

Tielsch, James ^{[25
]}

Taneja, Sunita ^{[26
]}

Chowdhury, Ranadip ^{[26
]}

Ashorn, Per ^{[27
,28
]}

Maleta, Kenneth ^{[29
]}

Ashorn, Ulla ^{[30
]}

Mangani, Charles ^{[29
]}

Mullany, Luke C. ^{[1
]}

Khatry, Subarna K. ^{[31
]}

Ramokolo, Vundli ^{[32
,33
]}

Zembe-Mkabile, Wanga ^{[34
,35
]}

Fawzi, Wafaie W. ^{[10
]}

Wang, Dongqing ^{[36
]}

Schmiegelow, Christentze ^{[37
,38
]}

Minja, Daniel ^{[39
]}

Msemo, Omari Abdul ^{[39
]}

Lusingu, John P. A. ^{[39
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Int Hlth Dept, Baltimore, MD USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Pediat Newborn Med, Boston, MA USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Human Nutr, Dept Int Hlth, Baltimore, MD USA

[4] BRAC JP Grant Sch Publ Hlth, Dhaka, Bangladesh

[5] JiVitA Maternal & Child Hlth Res Project, Rangpur, Bangladesh

[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA

[7] Child Hlth Res Fdn, Dhaka, Bangladesh

[8] Projahnmo Res Fdn, Dhaka, Bangladesh

[9] Univ Fed Pelotas, Postgrad Program Epidemiol, Pelotas, Brazil

[10] Harvard TH Chan Sch Publ Hlth, Boston, MA USA

[11] Beth Israel Deaconess Med Ctr, Boston, MA USA

[12] Univ Ghent, Dept Food Technol Safety & Hlth, Ghent, Belgium

[13] Int Food Policy Res Inst, Poverty Hlth & Nutr Div, Washington, DC USA

[14] Namur Univ, Namur, Belgium

[15] Belgian Hlth Care Knowledge Ctr, Brussels, Belgium

[16] Xi An Jiao Tong Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hlth Sci Ctr, Xian, Peoples R China

[17] Addis Ababa Univ, Sch Publ Hlth, Dept Nutr & Dietet, Addis Ababa, Ethiopia

[18] Univ Ghent, Fac Biosci Engn, Dept Food Technol Safety & Hlth, Ghent, Belgium

[19] Univ Ghana, Dept Nutr & Food Sci, Accra, Ghana

[20] Univ Calif Davis, Inst Global Nutr, Dept Nutr, Davis, CA USA

[21] Kintampo Hlth Res Ctr, Kintampo, Ghana

[22] Ghana Hlth Serv, Res & Dev Div, Accra, Ghana

[23] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA

[24] Aravind Eye Hosp, Madurai, India

[25] George Washington Univ Publ Hlth, Milken Inst Sch, Washington, DC USA

[26] Soc Appl Studies, Ctr Hlth Res & Dev, New Delhi, India

[27] Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland

[28] Tampere Univ Hosp, Tampere, Finland

[29] Kamuzu Univ Hlth Sci, Sch Global & Publ Hlth, Blantyre, Malawi

[30] Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland

[31] NNIPS, Kathmandu, Nepal

[32] South African Med Res Council, HIV & Other Infect Dis Res Unit, Cape Town, South Africa

[33] Columbia Univ, Vagelos Coll Phys & Surg, Gertrude Sergievsky Ctr H, Irving Med Ctr, New York, NY USA

[34] South African Med Res Council, Hlth Syst Res Unit, Cape Town, South Africa

[35] Univ South Africa, Coll Grad Studies, South African Res Chair Social Policy, Pretoria, South Africa

[36] George Mason Univ, Coll Publ Hlth, Dept Global & Community Hlth, Fairfax, VA USA

[37] Univ Copenhagen, Ctr Med Parasitol, Dept Immunol & Microbiol, Copenhagen, Denmark

[38] Copenhagen Univ Hosp, Dept Infect Dis, Copenhagen, Denmark

[39] Natl Inst Med Res, Tanga, Tanzania

[40] Milken Inst Sch Publ Hlth, Dept Global Hlth, Washington, DC USA

[41] Ifakara Hlth Inst, Dar Es Salaam, Tanzania

[42] Mahidol Univ, ASEAN Inst Hlth Dev, Salaya, Thailand

[43] Ubon Ratchathani Univ, Coll Med & Publ Hlth, Ubon Ratchathani, Thailand

[44] Infect Dis Res Collaborat, Kampala, Uganda

[45] Brigham & Womens Hosp, Ariadne Labs, Boston, MA USA

[46] Brigham & Womens Hosp, Dept Med, Div Global Hlth Equ, Boston, MA USA

[47] Harvard Med Sch, Dept Med, Boston, MA USA

[48] Boston Univ, Sch Publ Hlth, Dept Global Hlth, Boston, MA USA

[49] Boston Univ, Chobanian & Avedisian Sch Med, Dept Med, Sect Infect Dis, Boston, MA USA

[50] Univ Alabama Birmingham, Birmingham, AL USA

来源：

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2023年

关键词：

low-and middle-income countries; obstetrics and gynaecology; paediatrics; neonatal; preterm; small-for-gestational age; FOR-GESTATIONAL-AGE; MATERNAL MULTIPLE MICRONUTRIENT; INFANT-MORTALITY; PREGNANT-WOMEN; SOUTHERN NEPAL; UMBILICAL-CORD; PRETERM; CHLORHEXIDINE; OUTCOMES; WEIGHT;

D O I：

10.1111/1471-0528.17518

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective We aimed to understand the mortality risks of vulnerable newborns (defined as preterm and/or born weighing smaller or larger compared to a standard population), in low- and middle-income countries (LMICs).Design Descriptive multi-country, secondary analysis of individual-level study data of babies born since 2000.Setting Sixteen subnational, population-based studies from nine LMICs in sub-Saharan Africa, Southern and Eastern Asia, and Latin America.Population Live birth neonates.Methods We categorically defined five vulnerable newborn types based on size (large- or appropriate- or small-for-gestational age [LGA, AGA, SGA]), and term (T) and preterm (PT): T + LGA, T + SGA, PT + LGA, PT + AGA, and PT + SGA, with T + AGA (reference). A 10-type definition included low birthweight (LBW) and non-LBW, and a four-type definition collapsed AGA/LGA into one category. We performed imputation for missing birthweights in 13 of the studies.Main Outcome Measures Median and interquartile ranges by study for the prevalence, mortality rates and relative mortality risks for the four, six and ten type classification.Results There were 238 143 live births with known neonatal status. Four of the six types had higher mortality risk: T + SGA (median relative risk [RR] 2.8, interquartile range [IQR] 2.0-3.2), PT + LGA (median RR 7.3, IQR 2.3-10.4), PT + AGA (median RR 6.0, IQR 4.4-13.2) and PT + SGA (median RR 10.4, IQR 8.6-13.9). T + SGA, PT + LGA and PT + AGA babies who were LBW, had higher risk compared with non-LBW babies.Conclusions Small and/or preterm babies in LIMCs have a considerably increased mortality risk compared with babies born at term and larger. This classification system may advance the understanding of the social determinants and biomedical risk factors along with improved treatment that is critical for newborn health.

引用

页数：12

共 8 条

[1] Neonatal mortality risk of vulnerable newborns by fine stratum of gestational age and birthweight for 230679 live births in nine low- and middle-income countries, 2000-2017
Hazel, Elizabeth A.
Erchick, Daniel J.
Katz, Joanne
Lee, Anne C. C.
Diaz, Michael
Wu, Lee S. F.
West, Keith P., Jr.
Shamim, Abu Ahmed
Christian, Parul
Ali, Hasmot
Baqui, Abdullah H.
Saha, Samir K.
Ahmed, Salahuddin
Roy, Arunangshu Dutta
Silveira, Mariangela F.
Buffarini, Romina
Shapiro, Roger
Zash, Rebecca
Kolsteren, Patrick
Lachat, Carl
Huybregts, Lieven
Roberfroid, Dominique
Zhu, Zhonghai
Zeng, Lingxia
Gebreyesus, Seifu H.
Tesfamariam, Kokeb
Adu-Afarwuah, Seth
Dewey, Kathryn G.
Gyaase, Stephaney
Poku-Asante, Kwaku
Kaali, Ellen Boamah
Jack, Darby
Ravilla, Thulasiraj
Tielsch, James
Taneja, Sunita
Chowdhury, Ranadip
Ashorn, Per
Maleta, Kenneth
Ashorn, Ulla
Mangani, Charles
Mullany, Luke C.
Khatry, Subarna K.
Ramokolo, Vundli
Zembe-Mkabile, Wanga
Fawzi, Wafaie W.
Wang, Dongqing
Schmiegelow, Christentze
Minja, Daniel
Msemo, Omari Abdul
Lusingu, John P. A.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2024,
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Hazel, E. A.
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