Acute myeloid leukemia cutis with KMT2A::MLLT3 fusion presenting with leonine facies

被引：1
|
作者：
Wankel, Bret [1 ]
Afzal, Muhammad [2 ]
Loo, Eric Y. [3 ]
Leblanc, Robert E. [3 ]
Carter, Joi B. [4 ]
Lansigan, Erick [2 ]
Yerrabothala, Swaroopa [2 ]
机构：
[1] Dartmouth Hitchcock Med Ctr, Dept Internal Med, Lebanon, NH 03766 USA
[2] Dartmouth Hitchcock Med Ctr, Dept Hematol & Oncol, Lebanon, NH USA
[3] Dartmouth Hitchcock Med Ctr, Dept Pathol, Lebanon, NH USA
[4] Dartmouth Hitchcock Med Ctr, Dept Dermatol, Lebanon, NH USA
来源：
LEUKEMIA RESEARCH REPORTS | 2024年 / 21卷
关键词：
AML; Leukemia cutis; KMT2A; Leonine facies;
D O I：
10.1016/j.lrr.2023.100400
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A 63-year-old woman presented with plaques covering 60 % body-surface-area and leonine facies. Blood work showed no diagnostic aberrancies. Skin biopsy contained a malignant CD4+/CD56+ mononuclear cell population concerning for blastic plasmacytoid dendritic cell neoplasm. A later bone marrow biopsy confirmed AML with KMT2A::MLLT10 fusion detected by next-generation sequencing (NGS). This patient's LC preceded blood and marrow based symptoms of AML. NGS of the initial skin biopsy should be considered as part of diagnostic guidelines in cases with LC in the differential as this may have led to earlier diagnosis in this case and future cases.
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Loss of SMAD1 in acute myeloid leukemia with KMT2A::AFF1 and KMT2A::MLLT3 fusion genes
    Dietsche, Lisa
    Stirm, Kristin
    Lysenko, Veronika
    Schneidawind, Corina
    Tzankov, Alexandar
    Mueller, Anne
    Theocharides, Alexandre P. A.
    FRONTIERS IN ONCOLOGY, 2025, 14
  • [2] HMX3 is a critical vulnerability in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia
    Arza-Apalategi, Saioa
    Heuts, Branco M. H.
    Bergevoet, Saskia M.
    Meering, Roos
    Gilissen, Daan
    Jansen, Pascal W. T. C.
    Krippner-Heidenreich, Anja
    Valk, Peter J. M.
    Vermeulen, Michiel
    Heidenreich, Olaf
    Haferlach, Torsten
    Jansen, Joop H.
    Martens, Joost H. A.
    van der Reijden, Bert A.
    LEUKEMIA, 2025, 39 (02) : 371 - 380
  • [3] Cryptic KMT2A::MLLT10 Rearrangement in a Highly Aggressive Acute Myeloid Leukemia
    Tsilimidos, Gerasimos
    Scarpelli, Ilaria
    Solly, Francoise
    Gossin, Marine
    Segot, Amandine
    Schoumans, Jacqueline Pouw
    Blum, Sabine
    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2025,
  • [4] A single scalp nodule as the first presentation of acute lymphoblastic leukemia (KMT2A::MLLT3) in a healthy-appearing infant: a case report
    Pellegrino, Francesco
    Coppo, Paola
    Barisone, Elena
    Bertorello, Nicoletta
    Spadea, Manuela
    Fagioli, Franca
    FRONTIERS IN PEDIATRICS, 2023, 11
  • [5] A CASE OF MATURE B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA IN A 5-YEAR-OLD GIRL WITH KMT2A::MLLT3 (MLL::AF9) FUSION
    Urabe, Keisuke
    Kayatani, Rishu
    Katayama, Daisuke
    Sugita, Yuko
    Takitani, Kimitaka
    Ashida, Akira
    PEDIATRIC BLOOD & CANCER, 2024, 71 : S40 - S40
  • [6] A novel KMT2A::DCP1A fusion gene in acute myeloid leukemia
    Deng, Ailing
    Zhang, Fenghong
    Wang, Man
    Jiang, Dongyun
    Cen, Jiannong
    Xue, Mengxing
    Wang, Yun
    Dou, Xueqing
    Wu, Qian
    Yang, Xiaofei
    Chen, Suning
    LEUKEMIA RESEARCH, 2025, 149
  • [7] AMPLIFICATION OF THE KMT2A GENE IN A PATIENT WITH ACUTE MYELOID LEUKEMIA
    Agirre Maialen, Felipe
    Soley Desiree, Carbonell
    Moix Eulalia, Solsona
    Perez Lidia, Cusido
    Naima, Alaoui
    Monclus Alba, Verge
    Maria Jose, Sola Torres
    Porta Sandra, Espinagosa
    Vaquero Noelia, Redondo
    Martinez Claudia, Borras
    Riera Vicky, Blasco
    Gonzalez Cristina, Preciado
    Rangel Juana, Martos
    Perez Silvia, Leal
    Hijano Olga, Casablancas
    Salmeron Esther, Rodriguez
    Escobar Nuria, Pujol
    HAEMATOLOGICA, 2021, 106 (10) : 351 - 352
  • [8] Apparent coexistence of ETV6::RUNX1 and KMT2A::MLLT3 fusions due to a nonproductive KMT2A rearrangement in B-ALL
    Gagnon, Marie-France
    Smadbeck, James B.
    Sharma, Neeraj
    Blackburn, Patrick R.
    Demasi Benevides, Jonna
    Akkari, Yassmine M. N.
    Jaroscak, Jennifer J.
    Znoyko, Iya
    Wolff, Daynna J.
    Schandl, Cynthia A.
    Meyer, Reid
    Greipp, Patricia T.
    Xu, Xinjie
    Hoppman, Nicole L.
    Ketterling, Rhett P.
    Peterson, Jess F.
    Baughn, Linda B.
    LEUKEMIA & LYMPHOMA, 2022, 63 (09) : 2243 - 2246
  • [9] Cryptic KMT2A::AFDN Fusion Due to AFDN Insertion into KMT2A in a Patient with Acute Monoblastic Leukemia
    Wei, Qing
    Toruner, Gokce A.
    Thakral, Beenu
    Patel, Keyur P.
    Pemmaraju, Naveen
    Wang, Sa A.
    Kanagal-Shamanna, Rashmi
    Tang, Guilin
    Issa, Ghayas C.
    Loghavi, Sanam
    Medeiros, L. Jeffrey
    Dinardo, Courtney
    GENES, 2025, 16 (03)
  • [10] Predictors of outcomes in adults with acute myeloid leukemia and KMT2A rearrangements
    Issa, Ghayas C.
    Zarka, Jabra
    Sasaki, Koji
    Qiao, Wei
    Pak, Daewoo
    Ning, Jing
    Short, Nicholas J.
    Haddad, Fadi
    Tang, Zhenya
    Patel, Keyur P.
    Cuglievan, Branko
    Daver, Naval
    DiNardo, Courtney D.
    Jabbour, Elias
    Kadia, Tapan
    Borthakur, Gautam
    Garcia-Manero, Guillermo
    Konopleva, Marina
    Andreeff, Michael
    Kantarjian, Hagop M.
    Ravandi, Farhad
    BLOOD CANCER JOURNAL, 2021, 11 (09)
12345