SMARCA2 (BRM) degraders promotes differentiation and inhibit proliferation in AML models

被引：0
|
作者：
Agarwal, Anjana
Osinubi, Olusola Peace
Vykuntam, Komali
Fultang, Norman
Bhagwat, Neha
Heiser, Diane
Vaddi, Kris
Ito, Koichi
Scherle, Peggy
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-1594
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1594
引用
收藏
页数：2
相关论文
共 50 条
  • [1] SMARCA2/4 degraders relieve the differentiation block in AML via changes in chromatin looping and accessibility
    Aminov, Sarah
    Pradhan, Kith
    Sahu, Srabani
    Gordon-Mitchell, Shanisha
    Rabinovich, Emma
    Fromowitz, Ariel
    Chakraborty, Joyeeta
    Aluri, Srinivas
    Zhao, Rongbao
    Haque, Nayem
    Carbajal, Milagros
    Shastri, Aditi
    Steidl, Ulrich
    Samajdarr, Susanta
    Kumar, Akhil
    Ramachandra, Murali
    Coleman, Robert A.
    Stengel, Kristy
    Verma, Amit K.
    CANCER RESEARCH, 2024, 84 (06)
  • [2] The dual BRM/BRG1 (SMARCA2/4) inhibitor FHD-286 induces differentiation in preclinical models of AML
    Collins, Mike
    Thomsen, Astrid
    Gartin, Ashley
    Sandoval, Gabriel J.
    Adam, Ammar
    Reilly, Sarah
    Delestre, Laure
    Penard-Lacronique, Virginie
    Fiskus, Warren
    Bhalla, Kapil
    De Botton, Stephane
    Agresta, Sam
    Piel, Jessica
    Hentemann, Murphy
    CANCER RESEARCH, 2023, 83 (07)
  • [3] Combination therapy with selective SMARCA2 (BRM) degraders for treatment of SMARCA4 (BRG1)-deficient cancers
    Hulse, Michael
    Elkins, Margot
    Burtell, Jessica
    Vykuntam, Komali
    Vaddi, Kris
    Combs, Andrew
    Ito, Koichi
    Scherle, Peggy
    CANCER RESEARCH, 2023, 83 (07)
  • [4] Development of novel, selective SMARCA2 (BRM) degraders for treatment of SMARCA4 (BRG1) mutated tumors
    Mazan, Andrzej
    Wrobel, Anna
    Dreas, Agnieszka
    Radzimierski, Adam
    Michalik, Kinga
    Kowal, Anna
    Wiklik, Katarzyna
    Wnuk-Lipinska, Katarzyna
    Niedziejko, Paulina
    Kozlowska, Kamila
    Losko, Magdalena
    Szczesniak, Joanna
    Sroka-Porada, Agnieszka
    Martyka, Justyna
    Kulesza, Urszula
    Zuchowicz, Karol
    Zastawna, Magdalena
    Alvarez, Jose
    Stasi, Luigi
    Littlewood, Peter
    Rzymski, Tomasz
    Brzozka, Krzysztof
    CANCER RESEARCH, 2020, 80 (16)
  • [5] Bifunctional Compounds as SMARCA2 Degraders for Treating Cancer
    Sabnis, Ram W.
    ACS MEDICINAL CHEMISTRY LETTERS, 2021,
  • [6] BRM/SMARCA2 promotes the proliferation and chemoresistance of pancreatic cancer cells by targeting JAK2/STAT3 signaling
    Zhang, Zhengkui
    Wang, Feng
    Du, Chong
    Guo, Huahu
    Ma, Ling
    Liu, Xiaoran
    Kornmann, Marko
    Tian, Xiaodong
    Yang, Yinmo
    CANCER LETTERS, 2017, 402 : 213 - 224
  • [7] Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders
    Li, Zhenwu
    Harikrishnan, Lalgudi S.
    Xu, Guozhang
    Samanta, Debangshu
    Clemente, Jose C.
    Leng, Lingying
    Tu, Wenbin
    Yang, Lin
    Huang, Liyue
    Wang, Mi
    Wang, Shaomeng
    Deng, Qiaolin
    Behshad, Elham
    Nagilla, Rakesh
    Orth, Peter
    Rice, Cory
    Strickland, Corey
    Mohammad, Helai P.
    Priestley, E. Scott
    Sui, Zhihua
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 68 (02) : 1134 - 1154
  • [8] Development of potent, highly selective and efficacious SMARCA2 degraders
    Yang, Lin
    Tu, Wenbin
    Huang, Liyue
    Leng, Lingying
    Jiang, Wei
    Wang, Meilin
    Wen, Bo
    Sun, Duxin
    Stuckey, Jeanne
    Wang, Shaomeng
    CANCER RESEARCH, 2024, 84 (06)
  • [9] Discovery of oral SMARCA2 degraders for the treatment of SMARCA4 mutant tumors
    Clemente, Jose C.
    Harikrishnan, Lal
    Knight, Steve
    Samanta, Debangshu
    Li, Zhenwu
    Nagilla, Rakesh
    Kendsersky, Nathan
    Joshi, Shreyas
    Orth, Peter
    Tudor, Matt
    Deng, Qiaolin
    Aguilar-Bonavides, Clemente
    Behshad, Elham
    Sui, Zhihua
    Strickland, Corey
    Jolivette, Larry J.
    Mohammad, Helai P.
    CANCER RESEARCH, 2024, 84 (06)
  • [10] Identification of paralog selective degraders of SMARCA2 and SMARCA4 for treatment of various cancers
    Abbineni, Chandrasekhar
    Aithal, Kiran
    Khare, Leena
    Dukare, Sandeep, V
    Kuila, Bilash
    Goyal, Megha
    Rawoof, Khaji Abdul
    Mahadeo, Dhaytadak Bhagwan
    Kumar, Bhagya M. S.
    Premkumar, M.
    Sahu, Swetangini
    Gore, Suraj T.
    Krishna, Lavanya N.
    Charamanna, K. B.
    Gopinath, C. H.
    Samiulla, D. S.
    Mukherjee, Subhendu
    Antony, Thomas
    Gin, Sanjeev
    Chelur, Shekar
    Nellore, Kavitha
    Daginakatte, Girish
    Ramachandra, Murali
    Samajdar, Susanta
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
12345