Diabetes in HIV: the Link to Weight Gain

被引：9

作者：

Bailin, Samuel S. ^{[1
]}

Koethe, John R. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Dept Med, Med Ctr, Nashville, TN 37232 USA

[2] Tennessee Valley Hlth Syst, Dept Vet Affairs, Nashville, TN 37212 USA

来源：

CURRENT HIV/AIDS REPORTS | 2023年 / 20卷 / 01期

关键词：

Weight gain; Obesity; Type; 2; diabetes; Human immunodeficiency virus; HUMAN-IMMUNODEFICIENCY-VIRUS; STRAND TRANSFER INHIBITORS; FATTY LIVER-DISEASE; BODY-MASS INDEX; ANTIRETROVIRAL THERAPY; INFECTED PATIENTS; ADIPOSE-TISSUE; BARIATRIC SURGERY; DATA-COLLECTION; ADVERSE EVENTS;

D O I：

10.1007/s11904-022-00642-w

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose of Review The burden of metabolic diseases, including type 2 diabetes mellitus (T2DM), is rising among persons with HIV (PWH) on antiretroviral therapy (ART). This increase coincides with an aging population and a greater proportion who are overweight/obese. This review summarizes the changing epidemic of T2DM on contemporary ART, the role of weight gain, and therapeutic options. Recent Findings Recent studies confirm that PWH face an epidemic of obesity and T2DM, similar to the general population. Contemporary ART is associated with greater weight gain and may contribute to the risk of T2DM. Recent advances in medical weight loss therapy offer a way forward in the prevention and treatment of weight-associated T2DM. Summary Weight gain is one of the biggest contributors to T2DM in PWH. Future studies on the role of adipose tissue distribution, adipose tissue function and clinical use of effective weight loss medications may change the paradigm of care for PWH.

引用

页码：9 / 18

页数：10

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