In the information age we live in, we are constantly threatened by being drowned in a huge flood of information. Information overload (IO) describes this state where information can no longer be adequately processed by an individual. However, the danger posed by IO to individuals as well as organizations can still not be assessed properly due to a missing integration of previous findings. In this quantitative meta-analysis, we analysed the data of 133.011 people within 117 studies, and overall, 330 effect sizes. We performed multi-level as well as robust variance estimation analyses and found, among other things, positive correlations between IO and information avoidance, stress states, burnout and fatigue, and negative correlations between IO and performance and satisfaction. Explorative subgroup analyses revealed different moderating effects based on different vocational settings. Overall, the results of this meta-analysis indicate a negative relationship between IO and peoples' behaviour and experience, which call for an evaluation of the exchange and handling of information. Across a wide range of studies and contexts, this meta-analysis reveals that IO may provoke the information fatigue syndrome that has been poorly considered to date, leading to severe consequences in both work and home contexts.