Cold atmospheric plasma sensitizes melanoma cells to targeted therapy agents in vitro

被引：2
|
作者：
Yan, Cong [1 ]
Zhao, Lihong [1 ]
Zhang, Xinyue [1 ]
Chu, Zhaowei [1 ]
Zhou, Tong [1 ]
Zhang, Yanbin [2 ]
Geng, Songmei [1 ,3 ]
Guo, Kun [1 ,3 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Dermatol, Xian, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Oncol, Xian, Shaanxi, Peoples R China
[3] Precis Med Inst, Ctr Dermatol Dis, Xian, Peoples R China
来源：
JOURNAL OF BIOPHOTONICS | 2024年 / 17卷 / 03期
关键词：
cold atmospheric plasma; drug resistance; melanoma; targeted therapy; ACQUIRED-RESISTANCE; BRAF; INHIBITORS; MECHANISMS; EFFICACY; PATHWAY;
D O I：
10.1002/jbio.202300356
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Cold atmospheric plasma (CAP) has been reported to kill melanoma cells in vitro and in vivo. BRAF and MEK inhibitors are targeted therapy agents for advanced melanoma patients with BRAF mutations. However, low overall survival and relapse-free survival are still tough challenges due to drug resistance. In this study, we confirmed that CAP alleviated innate drug resistance and promoted the anti-tumor effect of targeted therapy in A875 and WM115 melanoma cells in vitro. Further, we revealed that CAP altered the expression of various molecules concerning MAPK and PI3K-AKT pathways in A875 cells. This study demonstrates that CAP promises to work as adjuvant treatment with targeted therapy to overcome drug resistance for malignant tumors in future. Cold atmospheric plasma alleviated innate drug resistance and promoted the anti-tumor effect of dabrafenib and trametinib in A875 and WM115 melanoma cells in vitro.image
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页数：11
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