Asymmetric addition of hydrazones as alkyl carbanion equivalents with aryl imines in water

被引：4
|
作者：
Wang, Yi-Zhan [1 ,2 ]
Liu, Shao-Dong [1 ,2 ]
Cheng, Liang [1 ,2 ]
Liu, Li [1 ,2 ]
Li, Chao-Jun [3 ,4 ]
机构：
[1] Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci BNLMS,CAS Key Lab Mol Rec, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada
[4] McGill Univ, FRQNT Ctr Green Chem & Catalysis, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada
来源：
ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 12期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
ORGANIC-SYNTHESIS; COMPLEXES; ALDEHYDES;
D O I：
10.1039/d3qo00475a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An asymmetric umpolung addition of hydrazones as alkyl carbanion equivalents with imines in water was developed under the catalysis of a Ru-diamine-diphosphine system in the presence of crown ether. Chiral amines were obtained in moderate to good yields with high enantioselectivities. The usage of water afforded better yields and enantioselectivities than that of organic solvents, which provided a new method for green and sustainable synthesis of chiral amines.
引用
收藏
页码：3021 / 3026
页数：6
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