Advances in Metal-Catalyzed Denitrogenative Pathways for N-Heterocycle Synthesis

For more than a century, cutting-edge research in organic chemistry has been the discovery of novel, powerful synthetic procedures to create very significant N-heterocyclic scaffolds. Nitrogen-containing heterocyclic scaffolds owing to their extensive abundance in natural products and bioactive compounds has gathered a growing attention in both academical and industrial sectors in pursuit of development of highly efficient clinical targets and drug candidates. Given the significance of nitrogen-rich compounds in contemporary science, significant efforts have been conducted over the past few decades investigating effective techniques for synthesis of N-heterocycles. Due to its intrinsic flexibility and extensive range of applications, catalytic denitrogenative reaction employing transition metal has differentiated itself as a cornerstone among numerous initiatives. In the present article we have outlined the most recent breakthroughs in metal-catalyzed denitrogenative reactions, for proactive synthesis N-heterocycles. [Graphical Abstract]