Agomelatine in the treatment of anhedonia, somatic symptoms, and sexual dysfunction in major depressive disorder

被引：3

作者：

Huang, Juan ^{[1
,2
,3
]}

Xie, Xiao-Meng ^{[1
,2
,3
]}

Lyu, Nan ^{[1
,2
,3
]}

Fu, Bing-Bing ^{[1
,2
,3
]}

Zhao, Qian ^{[1
,2
,3
]}

Zhang, Ling ^{[1
,2
,3
]}

Wang, Gang ^{[1
,2
,3
]}

机构：

[1] Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing Key Lab Mental Disorders, Beijing, Peoples R China

[2] Capital Med Univ, Beijing Anding Hosp, Natl Ctr Mental Disorders, Beijing, Peoples R China

[3] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China

来源：

FRONTIERS IN PSYCHIATRY | 2023年 / 14卷

关键词：

major depressive disorder; agomelatine; sexual dysfunction; anhedonia; somatic symptoms; QUALITY-OF-LIFE; STAR-ASTERISK-D; DOUBLE-BLIND; ANTIDEPRESSANT EFFICACY; REUPTAKE INHIBITORS; CHINESE VERSION; ANXIETY; RELIABILITY; FLUOXETINE; METAANALYSIS;

D O I：

10.3389/fpsyt.2023.1115008

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

ObjectiveThis study evaluated the treatment outcomes of agomelatine on anhedonic state, anxiety/somatic symptoms, and sexual function in Chinese patients with major depressive disorder (MDD). MethodIn total, 93 adult patients with MDD were enrolled, and 68 of them were included in a prospective, open-label, multicenter clinical study. All patients received agomelatine monotherapy during a 9-week treatment phase. The effectiveness of the treatment was reflected by the improvement of anhedonia and somatic symptoms based on the 17-item Hamilton Depression Rating Scale (HAMD-17). In addition, the Arizona Sexual Dysfunction Scale (ASEX), Sheehan Disability Scale (SDS), and Short Form of Quality-of-Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q-SF) were administered to all participants at baseline and at the 3-, 6-, and 9-week follow-ups. ResultsAfter 9 weeks of treatment with agomelatine, the response and remission rates were 73.5% and 39.7%, respectively. Somatic symptoms significantly improved at week 9 (p < 0.001), and significant effects were also observed on the HAMD anhedonia items (p < 0.001). The patients exhibited lower levels of disease severity (the SDS score dropped from 15.52 +/- 4.7 to 7.09 +/- 5.62 at week 9; the ASEX score dropped from 21.89 +/- 4.06 to 16.19 +/- 4.79, p < 0.001) and higher levels of QOL (the Q-LES-Q-SF score dropped from 41.02 +/- 5.99 to 50.49 +/- 8.57, p < 0.001) during the follow-up. Furthermore, treatment with agomelatine improved depressive symptoms without causing serious adverse events. ConclusionThese analyses indicate that agomelatine is a treatment option for improving anhedonic status, anxiety/somatic symptoms, and sexual dysfunction in MDD patients.

引用

页数：8