血清淀粉样蛋白A(SAA)升高的大动脉炎(TA)患者免疫炎症状态

被引：6

作者：

崔晓萌 ^{[1
]}

陈慧勇 ^{[1
]}

丁振奇 ^{[1
]}

纪宗斐 ^{[1
]}

杨程德 ^{[2
]}

邹耀红 ^{[3
]}

达展云 ^{[4
]}

万伟国 ^{[5
]}

戴晓敏 ^{[1
]}

闫焱 ^{[1
]}

孔秀芳 ^{[1
]}

马莉莉 ^{[1
]}

姜林娣 ^{[1
]}

机构：

[1] 复旦大学附属中山医院风湿免疫科

[2] 上海交通大学医学院附属瑞金医院风湿免疫科

[3] 无锡市人民医院风湿免疫科

[4] 南通大学附属医院风湿免疫科

[5] 复旦大学附属华山医院风湿科

来源：

复旦学报(医学版) | 2018年 / 06期

关键词：

大动脉炎(TA); 血清淀粉样蛋白A(SAA); 急性时相蛋白; 炎症; 免疫;

D O I：

暂无

中图分类号：

R593.2 [自身免疫性疾病、结缔组织疾病];

学科分类号：

摘要：

目的对伴有血清淀粉样蛋白A(serum amyloid A,SAA)升高的大动脉炎(Takayasu’s arteritis,TA)患者的临床特征、免疫炎症状态和疾病活动性进行分析。方法收集TA患者80例,比较SAA升高组和正常组患者一般资料、病情活动、炎症指标、细胞因子及用药情况差异,采用t检验、秩和检验和Spearman’s相关系数分析进行统计学分析。结果与SAA正常组相比,SAA升高组有更多患者Kerr评分≥2(86.44%vs.61.9%,P=0.036),红细胞沉降率(erythrocyte sedimentation rate,ESR)[(47.84±34.60)mg/L vs.(18.86±15.87)mg/L,P<0.001]、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)[17.42(5.20～36.90)mg/L vs.1.80(0.75～4.05)mg/L,P<0.001]、血小板数[(295.00±95.60)×109/L vs.(240.85±75.78)×109/L,P=0.025]、血清球蛋白水平[(29.05±6.49)g/L vs.(24.98±4.33)g/L,P=0.002]、IgG[(13.37±4.52)g/L vs.(11.63±2.63)g/L,P=0.048]、补体C3[(1.26±0.26)g/L vs.(1.03±0.20)g/L,P=0.002]、C4[0.25(0.21～0.29)g/L vs.0.20(0.14～0.23)g/L,P=0.008]及IL-6水平[(10.64±8.93)pg/mL vs.(3.88±2.72)pg/mL,P=0.001]显著高于SAA正常组。结论 SAA升高的TA患者炎症指标和疾病活动性更高,SAA检测有助于了解炎症和疾病状况。

引用

页码：793 / 798

页数：6

共 21 条

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