过氧化物酶体增生激活受体的共刺激因子-1α调节机制的研究进展

被引：2

作者：

李超英

李玲

机构：

[1] 中山大学附属第一医院神经内科

来源：

国际神经病学神经外科学杂志 | 2010年 / 37卷 / 06期

关键词：

过氧化物酶体增生激活受体共刺激因子-1α; 能量代谢; 线粒体; 腺苷酸活化蛋白激酶; 沉默信息调节因子;

D O I：

10.16636/j.cnki.jinn.2010.06.001

中图分类号：

R363 [病理生理学];

学科分类号：

摘要：

多种疾病可伴随着线粒体的功能障碍,引起细胞的能量衰竭,而过氧化物酶体增生激活受体的共刺激因子-1α(PGC-1α)作为核转录共刺激因子在氧化代谢及线粒体的生物合成中发挥非常重要的作用。PGC-1α的调节非常广泛而复杂,深入探索其调节机制有利于进一步认识各种疾病引起的PGC-1α的分子水平及相关信号传导的变化,本文就其正负性调节的研究进展做一综述。

引用

页码：542 / 547

页数：6

共 17 条

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