Follow-up of pregnancies after treatment of in vitro maturation of immature oocytes retrieved from PCOS patients with unstimulated cycles

<正>Objective:To follow up and analyze pregnancy outcomes obtained from treatment of in vitro maturation(IVM) of immature oocytes retrieved from women with polycystic ovary syndrome(PCOS) in unstimulated cycles. Methods:Data were collected from the Reproductive Medical Center of First Affiliated Hospital of Wenzhou Medical College.140 IVM cycles of 118 women with PCOS were treated.All children born were followed up.The multiple pregnancy rate,birth weight,premature rate,pregnancy complications,mode of delivery,growth retardation and congenital abnormalities were observed. Results:The clinical pregnancy rate was 40.17%(57/140),including 2 cases of ectopic pregnancies(3.5%), 35 cases of singletons(61.4%),17 cases of twins(29.82%) and 3 cases of triplets(5.26%).Among singletons, 7 cases were aborted at gestation of 7-14 weeks(12.28%).31 babies were delivered from 17 cases of twins,among them,one case was aborted at 22 week gestation,another case was received selective reduction to become singleton. 3 cases of triplets were all reduced into twins and 6 babies were delivered alive.All together,65 babies were born from 47 women in this study.The rate of multiple pregnancies,premature and infants with low weight were 36.36%(20/55),21.28%(10/47),and 26.15%(17/65),respectively.The general pregnancy complications rate was 26.32%(15/57). Conclusion:Our results showed no increasing pregnancy complications and congenital malformations in 65 babies born from women with PCOS in unstimulated IVM cycles.