The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin B1 (ITGB1)

被引：0

作者：

Ma HaiYang ^{[1
]}

Xu Yan ^{[1
]}

Qiao ChunYou ^{[2
]}

Peng Yi ^{[2
]}

Ding Qi ^{[3
]}

Wang LiZhong ^{[3
]}

Yan JunFei ^{[3
]}

Hou Yuan ^{[3
]}

Di Fei ^{[1
,3
]}

机构：

[1] Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

[2] Department of Endocrinology, ZhangJiakou First Hospital, Zhangjiakou, China

[3] Department of Neurosurgery, ZhangJiakou First Hospital, Zhangjiakou,

来源：

中华神经外科杂志（英文） | 2022年 / 08卷 / 01期

关键词：

Biomarker; Immunohistochemical staining; Inflammation; Integrins; Intracerebral hemorrhage; Western blotting;

D O I：

暂无

中图分类号：

R743.34 [脑出血];

学科分类号：

摘要：

Background: Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between the expression of ITGB1 and ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance.Methods: The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively.Results: Furthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues.Conclusions: In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.

引用

页码：10 / 15

页数：6

共 21 条

[1] Roles of blood-brain barrier integrins and extracellular matrix in stroke
Edwards, Danielle N.
Bix, Gregory J.
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2019, 316 (02): : C252 - C263
[2] Intracerebral Hemorrhage[J] . Ziai Wendy C,Carhuapoma J Ricardo.Continuum (Minneapolis, Minn.) . 2018 (6)
[3] Intracerebral haemorrhage: current approaches to acute management[J] . Charlotte Cordonnier,Andrew Demchuk,Wendy Ziai,Craig S Anderson.The Lancet . 2018 (1015)
[4] Every step of the way: integrins in cancer progression and metastasis[J] . Hamidi Hellyeh,Ivaska Johanna.Nature reviews. Cancer . 2018 (9)
[5] Management of Subdural Hematomas: Part I. Medical Management of Subdural Hematomas[J] . Fomchenko Elena I,Gilmore Emily J,Matouk Charles C,Gerrard Jason L,Sheth Kevin N.Current treatment options in neurology . 2018 (8)
[6] Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations
Dardiotis, Efthimios
Siokas, Vasileios
Zafeiridis, Tilemachos
Paterakis, Konstantinos
Tsivgoulis, Georgios
Dardioti, Maria
Grigoriadis, Savas
Simeonidou, Constantina
Deretzi, Georgia
Zintzaras, Elias
Jagiella, Jeremiasz
Hadjigeorgiou, Georgios M.
[J]. NEUROMOLECULAR MEDICINE, 2017, 19 (01) : 69 - 80
[7] Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function[J] . Lu Zhenwei,Mathew Sijo,Chen Jiang,Hadziselimovic Arina,Palamuttam Riya,Hudson Billy G,F?ssler Reinhard,Pozzi Ambra,Sanders Charles R,Zent Roy.eLife . 2016
[8] Diagnosis and Management of Acute Intracerebral Hemorrhage
Morotti, Andrea
Goldstein, Joshua N.
[J]. EMERGENCY MEDICINE CLINICS OF NORTH AMERICA, 2016, 34 (04) : 883 - +
[9] Pathogenesis of Brain Edema and Investigation into Anti-Edema Drugs
Michinaga, Shotaro
Koyama, Yutaka
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (05) : 9949 - 9975
[10] α4 Integrin Is a Regulator of Leukocyte Recruitment After Experimental Intracerebral Hemorrhage
Hammond, Matthew D.
Ambler, William G.
Ai, Youxi
Sansing, Lauren H.
[J]. STROKE, 2014, 45 (08) : 2485 - 2487

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