冠心病合并抑郁与基因多态性关系的研究进展

被引:7
|
作者
陈罗蔓
祁小龙
马文林
机构
[1] 同济大学附属同济医院
关键词
基因多态性; 抑郁症; CAD; ApoE; eNOS; PAI; 遗传多态性; 忧郁症; 情感性精神病; 冠心病患者; 血小板激动剂;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)]; R749.2 [躯体疾病伴发精神障碍];
学科分类号
摘要
<正>世界卫生组织和世界银行报道,抑郁和心血管疾病已成为全球的主要疾病经济负担之一[1]。流行病学调查显示,冠心病(coronary artery disease,CAD)人群中,抑郁现患率达14%47%,远高于普通人群的4%7%。1997年,Alexopoulous等[2]提出了"血管性抑郁"的概念,从一个侧面解释了抑郁产生的可能原因,即动脉粥样硬化可以使部分血管性疾病患者具有抑郁易感性,而动脉粥样硬化正是CAD的基
引用
收藏
页码:3259 / 3261
页数:3
相关论文
共 16 条
  • [1] 一氧化氮可能是导致抑郁症的主要因素[J]. 王丹.神经疾病与精神卫生. 2012 (01)
  • [2] 中青年冠心病患者焦虑抑郁状态的临床分析与对策研究
    李景隆
    叶国鸿
    白健雄
    陈春林
    曾智
    [J]. 实用医学杂志, 2012, 28 (02) : 237 - 238
  • [3] 载脂蛋白E基因多态性及超敏C-反应蛋白与冠心病相关性分析
    张鸿青
    马娟
    田青
    赵晓丽
    [J]. 云南医药, 2011, 32 (03) : 276 - 277
  • [4] 急性冠脉综合征患者焦虑抑郁情绪的随访[J]. 谢南姿,马文林,刘光辉,沈玉芹,陈罗蔓,周璐.老年医学与保健. 2013 (01)
  • [5] Decreased NOS1 Expression in the Anterior Cingulate Cortex in Depression
    Gao, Shang-Feng
    Qi, Xin-Rui
    Zhao, Juan
    Balesar, Rawien
    Bao, Ai-Min
    Swaab, Dick F.
    [J]. CEREBRAL CORTEX, 2013, 23 (12) : 2956 - 2964
  • [6] Low plasma levels of l -arginine, impaired intraplatelet nitric oxide and platelet hyperaggregability: Implications for cardiovascular disease in depressive patients[J] . Journal of Affective Disorders . 2012 (2)
  • [7] Association of plasma nitric oxide concentration and endothelial nitric oxide synthase T-786C gene polymorphism in coronary artery disease[J] . Saeedeh Salimi,Anoosh Naghavi,Mohsen Firoozrai,Hamid Zand,Heidar Tavilani,Alireza Nakhaee,Ahmad Mohebbi.Pathophysiology . 2012 (3)
  • [8] Nitric oxide plasma concentration associated with cognitive impairment in patients with recurrent depressive disorder
    Talarowska, Monika
    Galecki, Piotr
    Maes, Michael
    Orzechowska, Agata
    Chamielec, Marcelina
    Bartosz, Grzegorz
    Kowalczyk, Edward
    [J]. NEUROSCIENCE LETTERS, 2012, 510 (02) : 127 - 131
  • [9] ApoE Suppresses Atherosclerosis by Reducing Lipid Accumulation in Circulating Monocytes and the Expression of Inflammatory Molecules on Monocytes and Vascular Endothelium
    Gaudreault, Nathalie
    Kumar, Nikit
    Posada, Jessica M.
    Stephens, Kyle B.
    de Mochel, Nabora Soledad Reyes
    Eberle, Delphine
    Olivas, Victor R.
    Kim, Roy Y.
    Harms, Matthew J.
    Johnson, Sean
    Messina, Louis M.
    Rapp, Joseph H.
    Raffai, Robert L.
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (02) : 264 - U229
  • [10] ApoE4 and late onset depression in Indian population[J] . R. Sureshkumar,S. Bharath,S. Jain,O. Prakash,M. Purushottam,K. Thennarasu,O. Mukherjee,P.T. Sivakumar,M. Varghese.Journal of Affective Disorders . 2011 (3)