Basal physiological parameters in domesticated tree shrews (Tupaia belangeri chinensis)

被引:8
|
作者
Jing WANG [1 ,2 ]
XinLi XU [1 ,2 ]
ZeYang DING [1 ,3 ]
RongRong MAO [1 ]
QiXin ZHOU [1 ]
LongBao LV [4 ]
LiPing WANG [1 ]
Shuang WANG [1 ]
Chen ZHANG [1 ,5 ]
Lin XU [1 ,6 ]
YueXiong YANG [1 ]
机构
[1] Key Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences
[2] University of Chinese Academy of Sciences
[3] School of Life Sciences, Anhui University
[4] Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences
[5] Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine
[6] Tree Shrew Breeding Center, Kunming Institute of Zoology, the Chinese Academy of
关键词
Domesticated tree shrew; Basal physiological indexes; Rhythm; Glycometabolism; Stress-related hormone;
D O I
暂无
中图分类号
Q95-331 [实验动物的培养、管理及观测];
学科分类号
摘要
Establishing non-human primate models of human diseases is an efficient way to narrow the large gap between basic studies and translational medicine. Multifold advantages such as simplicity of breeding, low cost of feeding and facility of operating make the tree shrew an ideal non-human primate model proxy. Additional features like vulnerability to stress and spontaneous diabetic characteristics also indicate that the tree shrew could be a potential new animal model of human diseases. However, basal physiological indexes of tree shrew, especially those related to human disease, have not been systematically reported. Accordingly, we established important basal physiological indexes of domesticated tree shrews including several factors: (1) body weight, (2) core body temperature and rhythm, (3) diet metabolism, (4) locomotor rhythm, (5) electroencephalogram, (6) glycometabolism and (7) serum and urinary hormone level and urinary cortisol rhythm. We compared the physiological parameters of domesticated tree shrew with that of rats and macaques. Results showed that (a) the core body temperature of the tree shrew was 39.59±0.05 °C, which was higher than that of rats and macaques; (b) Compared with wild tree shrews, with two activity peaks, domesticated tree shrews had only one activity peak from 17:30 to 19:30; (c) Compared with rats, tree shrews had poor carbohydrate metabolism ability; and (d) Urinary cortisol rhythm indicated there were two peaks at 8:00 and 17:00 in domesticated tree shrews, which matched activity peaks in wild tree shrews. These results provided basal physiological indexes for domesticated tree shrews and laid an important foundation for diabetes and stress-related disease models established on tree shrews.
引用
收藏
页码:176 / 181
页数:6
相关论文
共 11 条
  • [1] 社会竞争失败病因学的抑郁症树鼩模型
    王静
    周启心
    吕龙宝
    徐林
    杨跃雄
    [J]. 动物学研究, 2012, 33 (01) : 92 - 98
  • [2] 清洁级SD大鼠血液生理及生化指标正常参考值的观察
    樊林花
    李丹
    刘茂林
    樊平花
    [J]. 中国医疗前沿, 2011, 6 (19) : 33 - 34+63
  • [3] 血管紧张素Ⅱ对大鼠心率和心率变异的影响
    李亘松
    邓欣
    罗丹
    章小芳
    李森
    王洋
    [J]. 解剖科学进展, 2011, 17 (04) : 364 - 367
  • [4] 非人灵长类糖尿病动物模型研究进展
    梁斌
    吴晓云
    [J]. 动物学研究, 2011, 32 (01) : 91 - 96
  • [5] 树鼩模型:抑郁症的社会竞争失败与学习和记忆的被捕获条件反射(英文)
    王静
    周启心
    田孟
    杨跃雄
    徐林
    [J]. 动物学研究, 2011, 32 (01) : 24 - 30
  • [6] 桂皮醛对麻醉大鼠降血压作用的实验研究
    徐明
    余璐
    丁媛媛
    王跃民
    王四旺
    裴建明
    [J]. 心脏杂志, 2006, (03) : 272 - 276
  • [7] 慢性温和应激抑郁模型大鼠5-羟色胺、色氨酸和应激激素的变化
    刘卫
    钱令嘉
    杨志华
    战锐
    冯红
    武磊
    [J]. 中国应用生理学杂志, 2006, (02) : 169 - 172
  • [8] 不同药物对心理应激猕猴的抗应激作用(英文)
    张力跃
    江燕
    田保平
    马原野
    王桂兰
    [J]. 云南大学学报(自然科学版), 1998, (03) : 41 - 43
  • [9] Social Stress in Tree Shrews as an Animal Model of Depression: An Example of a Behavioral Model of a CNS Disorder[J] . Eberhard Fuchs.CNS Spectrums . 2005 (3)
  • [10] The tree shrews: adjuncts and alternatives to primates as models for biomedical research[J] . JCao,E.‐BYang,J.‐JSu,YLi,PChow.Journal of Medical Primatology . 2003 (3)