Clinical Study on Long-Term Overall Survival of Advanced Non-Small-Cell Lung Cancer Patients Treated with Chinese Medicine and Western Medicine

Objective:To investigate the prognostic influence on long-term overall survival(OS) from treatment with Chinese medicine(CM) and chemotherapy or targeted therapy in advanced non-small-cell lung cancer(NSCLC) patients.Methods:The clinical data of 206 advanced NSCLC patients who were treated with CM and Western medicine in Beijing Cancer Hospital from April 1999 to July 2013 were retrospectively analyzed.Long-term survivors were defined as OS > 3 years after treatment with CM and chemotherapy.Twenty-eight patients had OS > 3 years,178 had OS < 3 years,and all clinical data were statistically analyzed with the Cox model.Variables were gender,age,smoking status,performance status(PS) score,pathological type,clinical stage,first-line chemotherapy,targeted therapy,and use of CM.Univariate survival analysis was performed using the Kaplan-Meier method and log-rank sequential inspection.Multivariate survival analysis was used to analyze the meaningful factors of univariate survival analysis with the Cox model.Results:The survival rate of patients with OS > 3 years was 13.6%(28/206).Cox multivariate regression analysis showed that PS score,clinical stage,disease control rate to first-line chemotherapy,and use of CM were independent factors of longterm OS(all P<0.05).However,gender,age,smoking,and use of epidermal growth factor receptor tyrosinekinase inhibitor were not significant(P>0.05).Conclusion:PS score,clinical stage,disease control rate to firstline chemotherapy,and use of CM are probably independent prognostic factors for long-term OS in patients with advanced NSCLC.