PD-1/PD-Ls与多发性硬化的相关性研究进展

被引:0
|
作者
洪香香
王毅飞
付锦
机构
[1] 哈尔滨医科大学附属第二医院神经内科
关键词
多发性硬化; 程序性死亡受体1/程序性死亡配体;
D O I
暂无
中图分类号
R744.51 [];
学科分类号
摘要
多发性硬化(multiple sclerosis, MS)是中枢神经系统(central nervous system, CNS)脱髓鞘性自身免疫病, 可表现为多种神经功能障碍, 具有高复发性、高致残性特点。目前MS发病机制尚不明确, 多数研究认为与异常免疫反应相关。程序性死亡受体1(programmed cell death 1, PD-1)属于共抑制分子, 与其配体(PD-1 ligands, PD-Ls)结合后, 在免疫反应中发挥负性调节作用。文章概述了PD-1/PD-Ls与MS的关系及其在MS发病机制中的作用。
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