miR26a-1 rs7372209和miR-612 rs12803915位点多态性与海南地区肺癌遗传易感性的关联研究

被引：0

作者：

周静 ^{[1
]}

邝仕成 ^{[2
]}

李逸轩 ^{[1
]}

蒙冲 ^{[3
]}

刘礼荣 ^{[3
]}

吕鹏飞 ^{[4
]}

祝朝勇 ^{[5
]}

洪运 ^{[1
]}

张婧 ^{[1
]}

曹文婷 ^{[1
]}

肖莎 ^{[1
]}

机构：

[1] 海南医学院公共卫生与全健康国际学院,热带环境与健康实验室,Heinz

来源：

现代肿瘤医学 | 2023年 / 31卷 / 16期

基金：

海南省自然科学基金;

关键词：

miR26a-1; miR-612; 单核苷酸多态性; 肺癌; 遗传易感性;

D O I：

暂无

中图分类号：

R734.2 [肺肿瘤];

学科分类号：

摘要：

目的:探讨海南地区人群miR26a-1(rs7372209,C>T)及miR-612(rs12803915,G>A)多态性是否与肺癌遗传易感性相关，为本地区人群肺癌的防治提供理论依据。方法:采用病例-对照的研究方法，征得符合纳入标准的研究对象同意后，对其进行问卷调查并采集外周静脉血，提取DNA,采用SNaPshot技术进行基因分型，利用卡方检验、Logistic回归分析等统计学方法分析两位点多态性与肺癌发生的关联强度。结果:本次调查共纳入病例组142名，对照组211名，两组年龄、性别及肿瘤家族史构成无差异(P=0.258、0.143、0.688)，病例组的吸烟率和饮酒率均显著高于对照组(P=0.002、0.023);校正混杂因素后，rs7372209位点突变等位基因T携带者(即CT和TT基因型)较携带野生基因型CC者的肺癌发生风险降低42%(OR=0.58,95%CI=0.37～0.90,P=0.016)，并且这种保护作用关联性在不吸烟人群(OR=0.50,95%CI=0.26～0.96,P=0.038)及不饮酒人群(OR=0.52,95%CI=0.31～0.86,P=0.011)中更为显著。结论:miR26a-1rs7372209位点T等位基因降低了海南地区人群，尤其是非吸烟和非饮酒人群的肺癌发生风险。

引用

页码：3018 / 3023

页数：6

共 12 条

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