Fibroblast growth factor (FGF)-21 signals through both FGF receptor-1 and 2

被引：0
|
作者：
REN GuiPing
机构：
来源：
Science China(Life Sciences) | 2010年 / 08期
关键词：
FGF-21; FGF receptor-1; FGF receptor-2; glucose metabolism; Glut1;
D O I：
暂无
中图分类号：
Q25 [细胞生理学];
学科分类号：
摘要：
Fibroblast growth factor (FGF)-21 is a member of the FGF superfamily based on sequence homology. However, unlike most members of this family it does not show any mitogenic activity in all cell types tested. The objective of this study is to identify and characterize receptors for this molecule. Sequencing of the cDNA clones from 3T3-L1 adipocytes indicates that the only isoforms for FGFR-1 and 2 expressed in 3T3-L1 cells are 1IIIc and 2IIIc, respectively, suggesting that FGF-21 regulates glucose metabolism in 3T3-L1 adipocytes through FGFR-1IIIc and FGFR-2IIIc.
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页码：1000 / 1008
页数：9
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