氧化应激与糖尿病周围神经病变的研究进展

被引：50
|
作者：
张倩
梁晓春
机构：
[1] 中国医学科学院北京协和医学院北京协和医院中医科
来源：
中华内分泌代谢杂志 | 2015年 / 31卷 / 11期
关键词：
糖尿病周围神经病变; 氧化应激; 活性氧簇;
D O I：
暂无
中图分类号：
R587.2 [糖尿病性昏迷及其他并发症];
学科分类号：
摘要：
氧化应激在糖尿病周围神经病变的发病机制中起到了关键作用。高血糖可引起线粒体电子传递链异常、NADPH氧化酶激活等生成活性氧簇,氧化损伤脂质、DNA、蛋白质,促进多个糖尿病周围神经病变的经典病理途径,诱导神经元和雪旺细胞凋亡,神经组织炎症,导致神经损伤。本文就氧化应激与糖尿病周围神经病变发病机制进行综述,为进一步探讨治疗策略提供线索。
引用
收藏
页码：1000 / 1003
页数：4
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