In this issue, NSR publishes an article entitled ‘Expression profiles of east-west highly differentiated genes in Uyghur genomes’ by Ning et al.(2023) [1]. Briefly, it is about the regulation of gene expression in Uyghur genomes, which are admixed between Asian and European genomes. In evolutionary terms, this is a case of post-isolation secondary contact over a time span of thousands of years. In most other cases, such as African Americans, the admixture has a time span of <300 years. Furthermore,