癌蛋白YAP1的研究进展

被引:11
|
作者
郭海强 [1 ]
刘同阳 [2 ]
贾舒婷 [1 ]
罗瑛 [1 ]
机构
[1] 昆明理工大学医学院
[2] 昆明理工大学生命科学与技术学院
关键词
YAP1; Hippo信号通路; 超激活; 增殖; 转移;
D O I
10.16476/j.pibb.2014.0248
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
摘要
Yes相关蛋白1(Yes-associated protein 1,YAP1)是Hippo信号通路(Hippo pathway)中的一个分子.早期研究人员发现,在Hippo信号通路正常的情况下,YAP1处于非激活状态;当Hippo信号通路中的某些分子出现突变时,YAP1处于超激活状态.此时,超激活状态下的YAP1可以促进细胞增殖、转移、生存(survival)以及维持干细胞活性.由于YAP1的超激活可以促进肿瘤的发生与发展,因此,YAP1被定义为一个癌蛋白.近期,研究者发现,YAP1的突变体与小细胞肺癌病人的存活率有一定关系,YAP1与链蛋白(catenin)、Kras相互作用,调节肿瘤细胞的转移侵袭能力,此外,部分micro RNA也与YAP1有相互作用.基于YAP1的功能,可以制定一些抗癌策略,寻找一些抗癌靶点.本文对当前YAP1的研究进行综述,为肿瘤治疗的基础及临床研究提供一些依据.
引用
收藏
页码:254 / 259
页数:6
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