HbE is the most common hemoglobin variant in the world.In compound heterozygotes,the interaction of HbE with othermutations in the β-globin gene results in HbE/β-thalasse-mia disease,which shows great variation in severity,includingcases that require blood transfusions just like the β-thalasse-mia major patients.Many hematologic disease could developmyelofibrosis.However,HbE/β-thalassemia with myelofibro-