基于GSK-3β信号通路防治骨质疏松的天然产物作用研究进展

被引：4

作者：

钟燕婷 ^{[1
,2
]}

杨亚军 ^{[1
]}

李嘉晓 ^{[3
]}

廖红波 ^{[1
]}

崔燎 ^{[1
,2
]}

机构：

[1] 广东医科大学药学院药理学教研室

[2] 广东医科大学广东天然药物研究与开发重点实验室

[3] 华南理工大学医学院

来源：

中国药理学通报 | 2022年 / 38卷 / 06期

基金：

广东省科技计划;

关键词：

植物; 天然产物; GSK-3β; 骨代谢; 骨质疏松; 机制;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

糖原合酶激酶-3β(glycogen synthase kinase-3β,GSK-3β)异常会引起骨代谢紊乱，导致骨质疏松，其特征是骨量丢失和骨微结构破坏，往往会增加骨折发生率。来源于植物的天然产物可以作为预防和治疗骨质疏松的潜在药物。该文综述了GSK-3β通路和骨代谢的密切联系，并阐述了黄酮类、异黄酮类、多糖和皂苷类、酚类、生物碱类、胺的衍生物类等天然产物调控GSK-3β信号通路防治骨质疏松的研究进展，为进一步开发可能有效防治骨质疏松的药物提供科学依据。

引用

页码：817 / 821

页数：5

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