Local advanced rectal cancer perforation in the midst of preoperative chemoradiotherapy:A case report and literature review

被引：0

作者：

Nobuhisa Takase ^{[1
]}

Kimihiro Yamashita ^{[1
]}

Yasuo Sumi ^{[1
]}

Hiroshi Hasegawa ^{[1
]}

Masashi Yamamoto ^{[1
]}

Shingo Kanaji ^{[1
]}

Yoshiko Matsuda ^{[1
]}

Takeru Matsuda ^{[1
]}

Taro Oshikiri ^{[1
]}

Tetsu Nakamura ^{[1
]}

Satoshi Suzuki ^{[1
]}

Yu-Ichiro Koma ^{[2
]}

Masato Komatsu ^{[3
,4
]}

Ryohei Sasaki ^{[5
]}

Yoshihiro Kakeji ^{[1
]}

机构：

[1] Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine

[2] Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine

[3] Division of Diagnostic Pathology, Department of Pathology, Kobe University Graduate School of Medicine

[4] Department of Surgery, Hyogo Cancer Center

[5] Department of Radiation Oncology, Kobe University Graduate School of Medicine

来源：

World Journal of Clinical Cases | 2017年 / 5卷 / 01期

关键词：

Local advanced rectal cancer; Preoperative chemoradiotherapy; Rectal perforation; 5-fluorouracil; Tumor necrosis;

D O I：

暂无

中图分类号：

R735.37 [];

学科分类号：

100214 ;

摘要：

Standard chemoradiotherapy(CRT) for local advanced rectal cancer(LARC) rarely induce rectal perforation. Here we report a rare case of rectal perforation in a patient with LARC in the midst of preoperative CRT. A 56-year-old male was conveyed to our hospital exhibiting general malaise. Colonoscopy and imaging tests resulted in a clinical diagnosis of LARC with direct invasion to adjacent organs and regional lymphadenopathy. Preoperative 5-fluorouracil-based CRT was started. At 25 d after the start of CRT, the patient developed a typical fever. Computed tomography revealed rectal perforation, and he underwent emergency sigmoid colostomy. At 12 d after the surgery, the remaining CRT was completed according to the original plan. The histopathological findings after radical operation revealed a wide field of tumor necrosis and fibrosis without lymph node metastasis. We share this case as important evidence for the treatment of LARC perforation in the midst of preoperative CRT.

引用

页码：18 / 23

页数：6

共 50 条

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