肝星形细胞凋亡机制的最新进展

被引:2
|
作者
樊文梅
石炳毅
机构
[1] 解放军第医院器官移植研究室
关键词
肝纤维化; 肝星形细胞; 凋亡;
D O I
暂无
中图分类号
R575.2 [肝硬变];
学科分类号
摘要
慢性肝病是全球重要死因之一,各种致病因素所致慢性肝损伤均可引起肝纤维化。近年来临床和实验数据均显示肝纤维化甚至肝硬化均可通过肝星形细胞(HSC)的凋亡而得以逆转,因此,阐明肝星形细胞凋亡的分子机制成为发展抗纤维化药物的重要途径之一。肝星形细胞的凋亡受多种因素调控,包括生长因子及其受体、自然杀伤细胞、细胞外基质组分、神经内分泌通路、药物制剂以及翻译后修饰均可影响肝星形细胞的凋亡。在此就各相关因素进行综述。
引用
收藏
页码:1797 / 1799
页数:3
相关论文
共 13 条
  • [1] Anti-proliferative and pro-apoptotic effects of tectorigenin on hepatic stellate cells[J]. Jun-Hua Wu, Yu-Rong Wang, Wu-Yang Huang, Ren-Xiang Tan, Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, Jiangsu Province, China. World Journal of Gastroenterology. 2010(31)
  • [2] Insulin-like growth factor binding protein-7 induces activation and transdifferentiation of hepatic stellate cells in vitro[J]. Li-Xin Liu,Qian-Qian Zhang,Experimental Center of Science and Research of The First Teaching Hospital of Shanxi Me dical University,Institute of Liver Disease of Shanxi Medical University and Key Laboratory of Cell Physiology,Provincial Department of the Ministry of Education,Taiyuan 030001,Shanxi Province,China Shuai Huang,Experimental Center of Science and Research of
  • [3] 去甲肾上腺素对肝星状细胞增殖和凋亡的影响
    刘娜
    张晓岚
    田晓鹏
    [J]. 中华肝脏病杂志, 2007, (10) : 746 - 748
  • [4] Effectiveness of the PPARγ agonist, GW570, in liver fibrosis[J] . Liu Yang,Stephen A. Stimpson,Lihong Chen,W. Wallace Harrington,Don C. Rockey. Inflammation Research . 2010 (12)
  • [5] Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells
    Shu, Jian-Chang
    He, Ya-Jun
    Lv, Xia
    Ye, Guo-Rong
    Wang, Le-Xin
    [J]. JOURNAL OF NATURAL MEDICINES, 2009, 63 (04) : 415 - 420
  • [6] Abrogation of the antifibrotic effects of natural killer cells/interferon-γ contributes to alcohol acceleration of liver fibrosis
    Jeong, Won-Il
    Park, Ogyi
    Gao, Bin
    [J]. GASTROENTEROLOGY, 2008, 134 (01) : 248 - 258
  • [7] Activation of natural killer cells inhibits liver fibrosis: a novel strategy to treat liver fibrosis[J] . Gao,Radaeva,Jeong. Expert Review of Gastroenterology & Hepatology . 2007 (1)
  • [8] Natural Killer Cells Ameliorate Liver Fibrosis by Killing Activated Stellate Cells in NKG2D-Dependent and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Dependent Manners[J] . Svetlana Radaeva,Rui Sun,Barbara Jaruga,Van T. Nguyen,Zhigang Tian,Bin Gao. Gastroenterology . 2006 (2)
  • [9] A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis
    Ruddell, Richard G.
    Oakley, Fiona
    Hussain, Ziafat
    Yeung, Irene
    Bryan-Lluka, Lesley J.
    Ramm, Grant A.
    Mann, Derek A.
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2006, 169 (03): : 861 - 876
  • [10] Antifibrogenic role of the cannabinoid receptor CB2 in the liver
    Julien, B
    Grenard, P
    Teixeira-Clerc, F
    Van Nhieu, JT
    Li, LY
    Karsak, M
    Zimmer, A
    Mallat, A
    Lotersztajn, S
    [J]. GASTROENTEROLOGY, 2005, 128 (03) : 742 - 755