丹参酮ⅡA抗肾间质纤维化作用机制的研究进展

被引：10
|
作者：
陈莎莎
李均
机构：
[1] 遵义医学院珠海校区
来源：
山东医药 | 2019年 / 59卷 / 14期
关键词：
丹参酮ⅡA; 肾间质纤维化; 慢性肾脏病; 慢性炎症; 氧化应激; 细胞凋亡; 微血管循环; 促纤维化因子;
D O I：
暂无
中图分类号：
R692 [肾疾病];
学科分类号：
摘要：
肾间质纤维化(RIF)是所有慢性肾脏病(CKD)发展的最终结果,也是导致终末期肾脏疾病的主要原因之一。RIF的发生发展过程复杂,是一种多致病因素、多机制参与的疾病,只干预孤立靶点的效果并不理想。丹参酮ⅡA是从丹参的根中提取的主要亲脂性成分,可通过抗炎、抗氧化应激、抗细胞凋亡、减少细胞外基质沉积、改善肾间质微血管循环、保护血管内皮、阻断细胞信号通路、抑制促纤维化因子的释放等作用,保护肾小管的正常结构和延缓RIF发生。
引用
收藏
页码：109 / 111
页数：3
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