Establishment of a cell-based assay to screen regulators for Klotho gene promoter

被引：0
|
作者：
Zhi-liang XU
Key Laboratory of Brain Functional Genomics of Ministry of Education
机构：
来源：
ActaPharmacologicaSinica | 2004年 / 09期
关键词：
<Keyword>Klotho protein; aging; biological factors; drug screening;
D O I：
暂无
中图分类号：
R346 [];
学科分类号：
1001 ;
摘要：
AIM: To discover compounds which can regulate Klotho promoter activity. Klotho is an aging suppressor gene. A defect in Klotho gene expression in the mouse results in the phenotype similar to human aging. Recombinant Klotho protein improves age-associated diseases in animal models. It has been proposed that up-regulation of Klotho gene expression may have anti-aging effects. METHODS: Klotho promoter was cloned into a
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页码：63 / 68
页数：6
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