miR-181b与肿瘤

被引:2
|
作者
刘娟
吴昌平
蒋敬庭
机构
[1] 苏州大学附属第三医院肿瘤生物诊疗中心
关键词
微小RNA; 癌基因; 抑癌基因;
D O I
10.13602/j.cnki.jcls.2012.09.035
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
摘要
microRNA(miRNA)是一类在转录后水平调控基因表达的单链非编码小分子RNA。miRNA能够调控机体多种生理和病理过程,如细胞增殖、分化、发育、凋亡、激素分泌和肿瘤形成等。在肿瘤中miR-181b与靶基因结合,作用相关信号通路,促进或抑制肿瘤生长,可作为判断某些肿瘤的生物标志物。对miR-181b与恶性肿瘤的发生、发展机制的研究具有重要意义,可为恶性肿瘤的诊断与治疗提供新的思路。
引用
收藏
页码:659 / 661
页数:3
相关论文
共 34 条
  • [1] hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells[J] . Lei Shi,Zihao Cheng,Junxia Zhang,Rui Li,Peng Zhao,Zhen Fu,Yongping You. &nbspBrain Research . 2008
  • [2] Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines. L. Wang,A.L. Oberg,Y.W. Asmann et al. PLoS One . 2009
  • [3] Extensive modulation of a set of microRNAs in primary glioblastoma
    Ciafrè, SA
    Galardi, S
    Mangiola, A
    Ferracin, M
    Liu, CG
    Sabatino, G
    Negrini, M
    Maira, G
    Croce, CM
    Farace, MG
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 334 (04) : 1351 - 1358
  • [4] miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines
    Zhu, Wei
    Shan, Xia
    Wang, Tongshan
    Shu, Yongqian
    Liu, Ping
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (11) : 2520 - 2529
  • [5] STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer
    Iliopoulos, Dimitrios
    Jaeger, Savina A.
    Hirsch, Heather A.
    Bulyk, Martha L.
    Struhl, Kevin
    [J]. MOLECULAR CELL, 2010, 39 (04) : 493 - 506
  • [6] Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma. Cervigne NK,Reis PP,Machado J, et al. Human Molecular Genetics . 2009
  • [7] MicroRNAs in Stress Signaling and Human Disease
    Mendell, Joshua T.
    Olson, Eric N.
    [J]. CELL, 2012, 148 (06) : 1172 - 1187
  • [8] MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. Schetter AJ,Leung SY,Sohn JJ,et al. The Journal of The American Medical Association . 2008
  • [9] MicroRNA biogenesis and cancer. Gregory R I,Shiekhattar R. Cancer Research . 2005
  • [10] MicroRNAs: genomics, biogenesis, mechanism and function. Bartel DP. Cell . 2004