颅脑损伤患者自然杀伤T细胞与性激素的相关性及其临床意义分析

被引：4

作者：

陈成

机构：

[1] 深圳市人民医院神经外科

来源：

立体定向和功能性神经外科杂志 | 2013年 / 26卷 / 02期

关键词：

颅脑损伤; 自然杀伤T细胞; 性激素; 体液免疫; 细胞免疫;

D O I：

暂无

中图分类号：

R651.15 [];

学科分类号：

摘要：

目的探索颅脑损伤患者自然杀伤T细胞与性激素的相关性及其临床意义。方法收集轻、中及重度颅脑损伤患者各30例,并选择20例健康体检者作为对照,在不同时间点采用流式细胞术检测自然杀伤T细胞(NKT)及其细胞因子白介素4(IL-4)及γ-干扰素(IFN-γ)含量,同时检测其性激素水平,并分析上述指标的相关性。结果与健康组比较,轻、中及重度颅脑损伤患者的NKT及IFN-γ均明显降低,且与损伤程度相关,呈现轻>中>重关系(P<0.05)。在患者就诊即刻、伤后24h及72h的三个时间点内,三组患者的NKT及IFN-γ均呈进行性下降趋势(P<0.05)。轻中重度颅脑损伤患者的IL-4高于健康对照组,且随着病情进展IL-4含量进行性升高(P<0.05)。雌二醇、孕酮及睾酮三者的变化趋势均与NKT及IFN-γ相反,其含量表现为轻<中<重,其随着时间的推演其含量进行性下降(P<0.05)。相关性分析显示NKT与IFN-γ呈正比,而与IL-4呈反比;NKT及IFN-γ与性激素三项均呈反比,IL-4与性激素三项呈正比,以上任意两者的相关性分析均有统计学意义(P<0.05)。结论 NKT及IFN-γ是脑损伤的一个保护性因素,且与性激素含量呈负相关性;而IL-4是颅脑损伤后的不利因素,后者可介导脑损伤后的体液免疫反应,从而加重病情。

引用

页码：85 / 89

页数：5

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