CD147和MMP-9在乳腺癌中的表达及其与微血管生成的相关性研究

被引：12

作者：

王祥军

吴新勇

何长青

蔡安庆

机构：

[1] 江苏省新沂市人民医院普通肿瘤外科(Ⅱ)病区

来源：

现代肿瘤医学 | 2010年 / 18卷 / 07期

关键词：

乳腺癌; CD147; 基质金属蛋白酶-9(MMP-9); 微血管密度(MVD);

D O I：

暂无

中图分类号：

R737.9 [乳腺肿瘤];

学科分类号：

摘要：

目的:探讨CD147和MMP-9在乳腺癌及癌旁组织中的表达及其与微血管密度(MVD)的关系。方法:应用免疫组化EnVision法检测50例乳腺癌及20例癌旁组织中CD147和MMP-9蛋白的表达情况,用CD34抗体标记乳腺癌血管内皮细胞,计算MVD。结果:乳腺癌组织中CD147的阳性表达率为60%(30/50);MMP-9的阳性表达率为66%(33/50),显著高于癌旁组织(P<0.01);CD147表达与淋巴结转移、TNM分期显著相关(P<0.05);与患者的年龄、肿瘤大小无明显相关性(P>0.05)。MMP-9表达与淋巴结转移、TNM分期、组织学分级显著相关(P<0.05);与患者的年龄、肿瘤大小无明显相关性(P>0.05)。乳腺癌组织中CD147、MMP-9蛋白表达之间存在显著正相关(r=0.630,P<0.01)。CD147、MMP-9阳性的乳腺癌组织MVD高于阴性者,差异有统计学意义(P<0.01)。结论:乳腺癌组织中存在CD147、MMP-9的高表达,两者之间存在显著正相关;CD147蛋白可通过诱导MMP-9蛋白的表达上调,促进乳腺癌侵袭、转移。

引用

页码：1318 / 1321

页数：4

共 11 条

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