Design,synthesis and antimycobacterial activity of novel nitrobenzamide derivatives

被引：0

作者：

Hongjian Wang ^{[1
]}

Kai Lv ^{[1
]}

Xiaoning Li ^{[1
]}

Bo Wang ^{[1
]}

Apeng Wang ^{[1
]}

Zeyu Tao ^{[1
]}

Yunhe Geng ^{[1
]}

Bin Wang ^{[2
]}

Menghao Huang ^{[3
]}

Mingliang Liu ^{[1
]}

Huiyuan Guo ^{[1
]}

Yu Lu ^{[2
]}

机构：

[1] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College

[2] Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing Chest Hospital, Capital Medical University

[3] Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine

来源：

Chinese Chemical Letters | 2019年 / 30卷 / 02期

关键词：

Nitrobenzamides; Synthesis; Antimycobacterial activity; Tuberculosis;

D O I：

暂无

中图分类号：

TQ465 [抗菌素制造];

学科分类号：

100705 ;

摘要：

We report herein the design and synthesis of a series of novel nitrobenzamide derivatives. Results reveal that many of them display considerable in vitro antitubercular activity. Four N-benzyl or N- (pyridine-2-yl)methyl 3,5-dinitrobenzamides A6, All, Cl and C4 have not only the same excellent MIC values of<0.016 μg/mL against both drug-sensitive MTB strain H37 Rv and two drug-resistant clinical isolates as PBTZ169 and the lead 1, but also acceptable safety indices (SI > 1500), opening a new direction for further development.

引用

页码：413 / 416

页数：4

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