Lamina cribrosa thickness in children with hyperopic anisometropic amblyopia

AIM:To determine lamina cribrosa thickness(LCT)in the optic nerve head region of the eyes in children with hyperopic anisometropic amblyopia and to compare this thickness with that of fellow eyes,hyperopic nonamblyopia,and age-matched controls.METHODS:Thirty-two patients(12.0±1.8y,mean±standard deviation)with hyperopic anisometropic amblyopia,31 subjects with age-and refractive error-matched hyperopic non-amblyopia(10.7±2.2y),and 32 age-matched controls(11.2±2.0y)were included in this prospective,crosssectional study.LCT was measured using an enhanced depth-imaging program of a spectral domain optical coherence tomographic instrument in all participants,and the correlation between LCT and axial length was calculated.RESULTS:The mean LCT was 180.9±29.4μm in amblyopic eyes,247.7±19.0μm in fellow eyes,251.6±27.3μm in hyperopic non-amblyopic eyes,and 240.2±15.8μm in control eyes.Lamina cribrosa in amblyopic eyes was significantly thinner than fellow,hyperopic non-amblyopic,and control eyes(P<0.05).There was no significant correlation in LCT and axial length between amblyopic(P=0.16)and control(P=0.31)group.CONCLUSION:Lamina cribrosa of eyes with hyperopic anisometropic amblyopia is significantly thinner than that of fellow eyes,hyperopic non-amblyopia,and age-matched controls.The LCT profile in amblyopic eyes is different from that observed in fellow,hyperopic non-amblyopic,and control eyes.