Alterations of DNA damage response pathway:Biomarker and therapeutic strategy for cancer immunotherapy

被引：12

作者：

Minlin Jiang ^{[1
,2
]}

Keyi Jia ^{[1
,2
]}

Lei Wang ^{[1
]}

Wei Li ^{[1
]}

Bin Chen ^{[1
]}

Yu Liu ^{[1
,2
]}

Hao Wang ^{[1
,2
]}

Sha Zhao ^{[1
]}

Yayi He ^{[1
]}

Caicun Zhou ^{[1
]}

机构：

[1] Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine

[2] Medical School, Tongji University

来源：

Acta Pharmaceutica Sinica B | 2021年 / 11卷 / 10期

基金：

中国国家自然科学基金;

关键词：

D O I：

暂无

中图分类号：

R730.51 [免疫疗法];

学科分类号：

100214 ;

摘要：

Genomic instability remains an enabling feature of cancer and promotes malignant transformation. Alterations of DNA damage response(DDR) pathways allow genomic instability, generate neoantigens, upregulate the expression of programmed death ligand 1(PD-L1) and interact with signaling such as cyclic GMPe AMP synthase-stimulator of interferon genes(cGASe STING) signaling. Here, we review the basic knowledge of DDR pathways, mechanisms of genomic instability induced by DDR alterations, impacts of DDR alterations on immune system, and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy.

引用

页码：2983 / 2994

页数：12

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