HLA ANTIGENS AND VOGT-KOYANAGI- HARADA'S DISEASE

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Qiang Yu Wenshu Mao Chufang Xie Shaozhen Li Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou
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HLA ANTIGENS AND VOGT-KOYANAGI; HARADA’S DISEASE;
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Thirty patients with Vogt-Koyanagi-Haradas disease were typed for HLA-A and HLA-B antigenic determinants by a microlymphocytotoxicity technique. HLA-B22 antigen showed an increased frequency of 43.3% in the patient group(relative risk=8.69; exact P<0.0001; corrected P<0.0025) compared with normal control group(frequency=7.69%). This association suggests that immunogenetic factor may play an important role in the pathogenesis of Vogt-Koyanagi-Harada’s disease.
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页码:3 / 5
页数:3
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