糖尿病肾病患者血脂异常与尿蛋白关系

被引：37

作者：

李军辉 ^{[1
]}

程东生 ^{[2
]}

王锋 ^{[2
]}

费杨 ^{[2
]}

薛勤 ^{[2
]}

汪年松 ^{[2
]}

机构：

[1] 苏州大学医学部

[2] 上海交通大学附属第六人民医院肾内科

来源：

上海交通大学学报 | 2016年 / 03期

关键词：

糖尿病肾病; 血脂异常; 非高密度脂蛋白胆固醇; 脂蛋白a; 尿蛋白;

D O I：

10.16183/j.cnki.jsjtu.2016.03.027

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症]; R692.9 [其他疾病];

学科分类号：

摘要：

探讨糖尿病肾病(DN)患者血脂异常与尿蛋白关系.选取122例住院的DN患者,年龄(62.26±12.67)岁,女性49例,男性73例,测定血脂代谢各指标,同时留取24h尿蛋白定量(24h pro),依据蛋白尿定量分为肾病和非肾病综合征组,比较两组相关血脂指标,并行相关性分析比较.肾病综合征组患者的TC(总胆固醇)、NHDL、Lpa和Apo-B水平均显著高于非肾病综合征组(P<0.05);TC、NHDL、Apo-B和Apo-E均分别与24h尿蛋白定量和糖化血红蛋白(HbA1C)相关(P<0.01),Lpa与24h尿蛋白定量及肾小球滤过率(eGFR)相关,LDL-C及TG仅与HbA1C相关(P<0.01),Apo-A1仅与24hpro相关(P<0.05);各血脂指标依据四分位法分组,TC、NHDL-C、TG、Apo-A1、Apo-B、Lpa及Apo-E随着数值升高,组内24h尿蛋白定量(≥3.5g)百分比例增高(P<0.05),而LDL-C及HDL-C组内比较无统计学差异(P>0.05).DN患者随着24h蛋白尿增多,血脂异常更为显著,尤其在肾病综合征患者以TC、NHDL、Lpa及Apo-B升高为主,而血脂异常进一步加重肾脏病进展,有效控制血脂有望改善肾脏病预后.

引用

页码：478 / 482

页数：5

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