Image-based nonlinear finite element analysis for the assessment of bone strength

<正>Introduction As a major component of musculoskeletal system,bones support body weight,facilitate body motion,protect internal organs,and also play critical roles in mineral homeostasis.Osteoporosis,one of the most common bone diseases,is a result of imbalance in bone metabolism that causes low bone mass and micro-architectural deterioration.The inferior quality of osteoporotic bone leads to a consequent increase in bone fragility and susceptibility to fracture.It is known that osteoporotic fractures occur most frequently in trabeculae-rich skeletal sites such as spine,hip,distal radius,and ankle.With the great increase in the number of senile population,