脑白质损害与帕金森病认知功能障碍的研究进展

被引：23
|
作者：
唐红梅
张玉虎
王丽娟
机构：
[1] 广东省人民医院(广东省医学科学院)神经内科广东省神经科学研究所
来源：
中华老年心脑血管病杂志 | 2014年 / 16卷 / 03期
基金：
广东省科技计划; 广州市科技计划项目; 广东省自然科学基金;
关键词：
脑白质疏松症; 帕金森病; 认知障碍; 血脑屏障; 少突神经胶质;
D O I：
暂无
中图分类号：
R742.5 [震颤麻痹综合征];
学科分类号：
摘要：
<正>帕金森病(PD)是继阿尔茨海默病(AD)后人类第二大神经退行性疾病,由中脑黑质致密部多巴胺变性脱失引起,临床主要表现为运动症状和非运动症状,其中PD认知功能障碍近年来备受关注,包括PD轻度认知功能障碍和PD痴呆,随着病情的逐步进展,PD轻度认知功能障碍最终可发展为PD痴呆,给家庭和社会带来沉重负担,还增加PD患者的致残风险、死亡率和病死率[1-2]。PD患者从发病到进展为痴呆少则3～5年,多则20～30年,因此,对PD认知障碍患者
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页码：327 / 329
页数：3
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