Non-traditional risk factors for atrial fibrillation: epidemiology, mechanisms, and strategies

被引:3
|
作者
Lu, Yingli [1 ]
Sun, Ying [1 ]
Cai, Lingli [1 ]
Yu, Bowei [1 ]
Wang, Yuying [1 ]
Tan, Xiao [2 ,3 ]
Wan, Heng [4 ]
Xu, Dachun [5 ]
Zhang, Junfeng [6 ]
Qi, Lu [7 ,8 ]
Sanders, Prashanthan [9 ,10 ]
Wang, Ningjian [1 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China
[2] Zhejiang Univ, Sch Publ Hlth, Hangzhou, Peoples R China
[3] Uppsala Univ, Dept Med Sci, Uppsala, Sweden
[4] Southern Med Univ, Shunde Hosp, Peoples Hosp Shunde 1, Dept Endocrinol & Metab, Foshan, Guangdong, Peoples R China
[5] Tongji Univ, Shanghai Peoples Hosp 10, Dept Cardiol, Clin Res Unit,Sch Med, Shanghai, Peoples R China
[6] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Cardiol, Shanghai, Peoples R China
[7] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA
[8] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA
[9] Univ Adelaide, Ctr Heart Rhythm Disorders, Adelaide, Australia
[10] Royal Adelaide Hosp, Dept Cardiol, Adelaide, Australia
基金
中国国家自然科学基金;
关键词
Atrial fibrillation; Non-traditional risk factor; Lifestyle; Biomarker; Adverse condition or disease; Environmental factor; NIGHT-SHIFT WORK; CLONAL HEMATOPOIESIS; CARDIOVASCULAR-DISEASES; SLEEP DURATION; VEGETARIAN DIETS; AMERICAN ACADEMY; VIRUS-INFECTION; BLOOD-PRESSURE; AIR-POLLUTION; HEART-DISEASE;
D O I
10.1093/eurheartj/ehae887
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Atrial fibrillation (AF) has become the pre-dominant arrhythmia worldwide and is associated with high morbidity and mortality. Its pathogenesis is intricately linked to the deleterious impact of cardiovascular risk factors, emphasizing the pivotal imperative for early detection and mitigation strategies targeting these factors for the prevention of primary AF. While traditional risk factors are well recognized, an increasing number of novel risk factors have been identified in recent decades. This review explores the emerging non-traditional risk factors for the primary prevention of AF, including unhealthy lifestyle factors in current society (sleep, night shift work, and diet), biomarkers (gut microbiota, hyperuricaemia, and homocysteine), adverse conditions or diseases (depression, epilepsy, clonal haematopoiesis of indeterminate potential, infections, and asthma), and environmental factors (acoustic pollution and other environmental factors). Unlike traditional risk factors, individuals have limited control over many of these non-traditional risk factors, posing challenges to conventional prevention strategies. The purpose of this review is to outline the current evidence on the associations of non-traditional risk factors with new-onset AF and the potential mechanisms related to these risk factors. Furthermore, this review aims to explore potential interventions targeting these risk factors at both the individual and societal levels to mitigate the growing burden of AF, suggesting guideline updates for primary AF prevention.
引用
收藏
页码:784 / 804
页数:21
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