Progresses in the Preparation of Chromone Compounds and Their Applications in Organic Synthesis

Chromone is the core backbone of flavonoids and its derivatives have different applications. Meanwhile, the alpha , beta-unsaturated ketone structure contained in chromones enables them to undergo reactions such as substitution, cyclization, and asymmetric addition, which promotes the generation of a variety of functionalized chromone analogues or other backbone molecules. Therefore, in addition to chromone natural products, the preparation of chromones and their use as synthons in organic synthesis applications are also of great interest. The preparation methods of chromones are summarized and the recent applications of important chromone synthons in organic synthesis are reviewed on the basis of reaction types and reaction regions.