Lewis Acid Promotes Three-Component Cyclization to Construct Dithioxazole Derivatives

被引：0
|
作者：
Zou, Kai [1 ]
Li, Anquan [1 ]
Chen, Yitong [1 ]
Cao, Gao [1 ]
Zhu, Baofu [1 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 23期
关键词：
DISULFIDE; ANTAGONISTS; REACTIVITY;
D O I：
10.1021/acs.joc.4c01723
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and effective strategy for the construction of disulfide-substituted oxazole derivatives from amides, ynals, and acetyl disulfides via a Lewis acid-promoted three-component reaction has been reported. In addition, this reaction possesses other unique advantages, such as transition-metal-free catalysis, the production of disulfides, good functional group tolerance, and good regioselectivity.
引用
收藏
页码：17228 / 17236
页数：9
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