This study examined how Puerto Rican parents living in the United States reason about illnesses and remedies. Special focus is placed on the influence of Puerto Rican cultural, religious, and spiritual beliefs due to the influence of Taino, West African, Spanish, and U.S. beliefs and customs. Parents of 3.5 to 12-year-old children from the Rochester, NY area were asked to complete a questionnaire centered on their beliefs and an open-ended interview that explored how one could get sick and treated for biological illnesses (e.g., the common cold, COvID-19, cancer). Although participants reported religious, spiritual, and mystical beliefs in the questionnaire, they provided scientific explanations for illness and remedies in the interview. This study provides novel findings on how individuals of Puerto Rican descent understand illnesses and remedies and the variation across individuals. This study provides strong evidence for the variation in coexistence of beliefs within this population.