CircAars-Engineered ADSCs Facilitate Maxillofacial Bone Defects Repair Via Synergistic Capability of Osteogenic Differentiation, Macrophage Polarization and Angiogenesis
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作者:
He, Yi
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
He, Yi
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Lu, Yunyang
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Lu, Yunyang
[1
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Li, Runze
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Li, Runze
[1
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Tang, Yuquan
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R China
Guangzhou Liwan Dist Stomatol Hosp, Guangzhou 510080, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Tang, Yuquan
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Du, Weidong
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Du, Weidong
[1
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Zhang, Lejia
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Zhang, Lejia
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Wu, Jie
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Wu, Jie
[1
,2
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Li, Kechen
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Li, Kechen
[1
,2
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Zhuang, Weijie
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Zhuang, Weijie
[1
,2
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Lv, Shiyu
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Lv, Shiyu
[1
,2
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Han, Yaoling
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Han, Yaoling
[1
,2
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Tao, Bailong
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R China
Chongqing Med Univ, Affiliated Hosp 1, Lab Res Ctr, Chongqing 400016, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Tao, Bailong
[1
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Deng, Feilong
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Deng, Feilong
[1
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Zhao, Wei
论文数: 0引用数: 0
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机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Zhao, Wei
[1
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Yu, Dongsheng
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R ChinaSun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
Yu, Dongsheng
[1
,2
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机构:
[1] Sun Yat Sen Univ, Hosp Stomatol, Inst Stomatol Res, Guanghua Sch Stomatol, Guangzhou 510080, Peoples R China
[2] Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R China
[3] Guangzhou Liwan Dist Stomatol Hosp, Guangzhou 510080, Peoples R China
[4] Chongqing Med Univ, Affiliated Hosp 1, Lab Res Ctr, Chongqing 400016, Peoples R China
Adipose-derived stem cells (ADSCs) hold significant promise in bone tissue engineering due to their self-renewal capacity and easy accessibility. However, their limited osteogenic potential remains a critical challenge for clinical application in bone repair. Emerging evidence suggests that circular RNAs (circRNAs) play a key role in regulating stem cell fate and osteogenesis. Despite this, the specific mechanisms by which circRNAs influence ADSCs in the context of bone tissue engineering are largely unexplored. This study introduces a novel strategy utilizing circAars, a specific circRNA, to modify ADSCs, which are then incorporated into gelatin methacryloyl (GelMA) hydrogels for the repair of critical-sized maxillofacial bone defects. The findings reveal that circAars predominantly localizes in the cytoplasm of ADSCs, where it acts as a competitive sponge for miR-128-3p, enhancing the osteogenic differentiation and migration capabilities of ADSCs. Furthermore, circAars-engineered ADSCs facilitate macrophage polarization from the M1 to M2 phenotype and enhance endothelial cell (EC) angiogenic potential through a paracrine mechanism. Additionally, GelMA scaffolds loaded with circAars-engineered ADSCs accelerate the repair of critical-sized maxillofacial bone defects by synergistically promoting osteogenesis, macrophage M2 polarization, and angiogenesis. This approach offers a promising therapeutic strategy for the treatment of critical-sized maxillofacial defects.
机构:
Wuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R China
Hu, Yan
Tang, Lixi
论文数: 0引用数: 0
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机构:
China Three Gorges Univ, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Yichang 443002, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R China
Tang, Lixi
Wang, Zheng
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机构:
Wuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R China
Wang, Zheng
Yan, Honghan
论文数: 0引用数: 0
h-index: 0
机构:
China Three Gorges Univ, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Yichang 443002, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R China
Yan, Honghan
Yi, Xinzeyu
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R China
Yi, Xinzeyu
Wang, Huimin
论文数: 0引用数: 0
h-index: 0
机构:
China Three Gorges Univ, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Yichang 443002, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R China
Wang, Huimin
Ma, Liya
论文数: 0引用数: 0
h-index: 0
机构:
Core Facil Wuhan Univ, Wuhan Univ, Wuhan 430072, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R China
Ma, Liya
Yang, Changying
论文数: 0引用数: 0
h-index: 0
机构:
China Three Gorges Univ, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Yichang 443002, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R China
Yang, Changying
Ran, Jiabing
论文数: 0引用数: 0
h-index: 0
机构:
China Three Gorges Univ, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Yichang 443002, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R China
Ran, Jiabing
Yu, Aixi
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430000, Peoples R China
机构:
Southwest Univ, Inst Clean Energy & Adv Mat, Fac Mat & Energy, Chongqing, Peoples R China
Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Orthoped, Chongqing, Peoples R ChinaSouthwest Univ, Inst Clean Energy & Adv Mat, Fac Mat & Energy, Chongqing, Peoples R China
Han, Xinyun
Hu, Junxian
论文数: 0引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Orthoped, Chongqing, Peoples R ChinaSouthwest Univ, Inst Clean Energy & Adv Mat, Fac Mat & Energy, Chongqing, Peoples R China
Hu, Junxian
Zhao, Wenbo
论文数: 0引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Orthoped, Chongqing, Peoples R ChinaSouthwest Univ, Inst Clean Energy & Adv Mat, Fac Mat & Energy, Chongqing, Peoples R China
Zhao, Wenbo
Lu, Hongwei
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h-index: 0
机构:
Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Orthoped, Chongqing, Peoples R ChinaSouthwest Univ, Inst Clean Energy & Adv Mat, Fac Mat & Energy, Chongqing, Peoples R China
Lu, Hongwei
Dai, Jingjin
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h-index: 0
机构:
Third Mil Med Univ, Army Med Univ, Dept Biomed Mat Sci, Chongqing, Peoples R ChinaSouthwest Univ, Inst Clean Energy & Adv Mat, Fac Mat & Energy, Chongqing, Peoples R China
Dai, Jingjin
He, Qingyi
论文数: 0引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Orthoped, Chongqing, Peoples R ChinaSouthwest Univ, Inst Clean Energy & Adv Mat, Fac Mat & Energy, Chongqing, Peoples R China