Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia

被引：1

作者：

Ma, Ruihua ^{[1
]}

Prigge, Andrew D. ^{[2
]}

Serrano, Tatiana P. Ortiz ^{[1
]}

Cheng, Yuan ^{[1
]}

Davis, Jennifer M. ^{[1
]}

Lou, Karen F. ^{[1
]}

Wood, Walter A. ^{[1
]}

Do, Hanh Chi ^{[1
]}

Ren, Ziyou ^{[4
]}

Fulcer, McKenzie M. ^{[1
]}

Lotesto, Mary J. ^{[1
]}

Singer, Benjamin D. ^{[1
]}

Coates, Bria M. ^{[2
]}

Ridge, Karen M. ^{[1
,3
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Pulm & Crit Care, Chicago, IL 60611 USA

[2] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Cell & Dev Biol, Chicago, IL 60611 USA

[4] Northwestern Univ, Feinberg Sch Med, Dept Dermatol, Chicago, IL 60611 USA

来源：

CELL REPORTS | 2024年 / 43卷 / 12期

关键词：

LUNG INJURY; IN-VIVO; ADENOSINE; EXPRESSION; PROTEIN; TREG; MACROPHAGES; HELIOS; CD73; CD39;

D O I：

10.1016/j.celrep.2024.115056

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Forkhead box P3 (Foxp3)+ regulatory T cells (Tregs) resolve acute inflammation and repair the injured lung after viral pneumonia. Vimentin is a critical protein in the distal pole complex (DPC) of Tregs. This study reveals the inhibitory effect of vimentin on the suppressive and reparative capacity of Tregs. Treg-specific deletion of vimentin increases Helios+interleukin-18 receptor (IL-18R)+ Tregs, suppresses inflammatory immune cells, and enhances tissue repair, protecting Vim fl/fl Foxp3 YFP-cre mice from influenza-induced lung injury and mortality. Mechanistically, vimentin suppresses the induction of amphiregulin, an epidermal growth factor receptor (EGFR) ligand necessary for tissue repair, by sequestering IL-18R to the DPC and restricting receptorligand interactions. We propose that vimentin in the DPC of Tregs functions as a molecular switch, which could be targeted to regulate the immune response and enhance tissue repair in patients with severe viral pneumonia.

引用

页数：25

共 1 条

[1] CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation
Choi, Sung W.
Hildebrandt, Gerhard C.
Olkiewicz, Krystyna M.
Hanauer, David A.
Chaudhary, Meghana N.
Silva, Ines A.
Rogers, Clare E.
Deurloo, Daphne T.
Fisher, Jacki M.
Liu, Chen
Adams, David
Chensue, Stephen W.
Cooke, Kenneth R.
BLOOD, 2007, 110 (09) : 3447 - 3455

← 1 →