Unraveling L-asparaginase adverse reactions in paediatric acute lymphocytic leukaemia - A comprehensive case series from a paediatric oncology unit at a tertiary care center

被引：0

作者：

Kushwah, Anjali ^{[1
,3
]}

Kamle, Akshay ^{[2
]}

Malpani, Preeti ^{[2
]}

Chaudhary, Prachi ^{[2
]}

Mishra, Pooja Solanki ^{[1
]}

Acharya, Preeti ^{[1
]}

机构：

[1] Mahatma Gandhi Mem Med Coll, Dept Orthopaed, Indore 452001, Madhya Pradesh, India

[2] Mahatma Gandhi Mem Med Coll, Dept Orthopaed, Indore 452001, Madhya Pradesh, India

[3] MGM Med Coll, Dept Pharmacol, Indore 452001, MP, India

来源：

JOURNAL OF KRISHNA INSTITUTE OF MEDICAL SCIENCES UNIVERSITY | 2024年 / 13卷 / 03期

关键词：

L-; asparaginase; hypersensitivity reactions; acute lymphocytic leukaemia; ACUTE LYMPHOBLASTIC-LEUKEMIA; ESCHERICHIA-COLI ASPARAGINASE; CHILDREN;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This case series explores adverse reactions to E coli L-Asparaginase in paediatric Acute Lymphoblastic Leukemia (ALL). Five cases illustrate several complications, including hyperbilirubinemia, pancreatitis, and hypersensitivity reactions. Asparaginase is integral to paediatric ALL chemotherapy, but its use introduces potential toxicities, including hypersensitivity, pancreatitis, and liver dysfunction. The synthesis of the case series and review contributes to understanding challenges and strategies associated with L-asparaginase therapy in paediatric ALL, emphasizing the need for precision in managing adverse reactions for maximized treatment benefits.

引用

页码：174 / 179

页数：6