In silico Exploration of the Therapeutic Potential of Alkaloids as Anti-infective Agents

被引：0
|
作者：
Rani, Nidhi [1 ]
Kumar, Praveen [2 ]
Walia, Aditya [1 ]
Singh, Randhir [3 ]
机构：
[1] Chitkara Univ, Chitkara Coll Pharm, Chitkara, Punjab, India
[2] SunPharma, Hill Top Area,PO Barotiwala, Solan 174103, Himachal Prades, India
[3] Cent Univ Punjab, Dept Pharmaceut Sci, Bathinda, Punjab, India
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2024年 / 21卷 / 15期
关键词：
ADMET study; alkaloids; 14; alpha-demethylase; molecular docking; omicron; transpeptidase; MOLECULAR DOCKING; DESIGN;
D O I：
10.2174/0115701808276535231212071700
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Background: Alkaloids are important phytoconstituents obtained from various plant sources. Methods: The main objective of the study was to evaluate the anti-infective potential of alkaloids against 14 alpha-demethylase, transpeptidase, and omicron spike protein using molecular docking studies. The potential constituents were identified and an ADMET study was performed. Results: The study concluded that reserpine and tubocurarine exhibited potential activity against the three tested enzymes with good ADMET profile. Conclusion: Reserpine and tubocurarine can further be explored to attain new candidates as anti-infective agents.
引用
收藏
页码：3307 / 3318
页数：12
相关论文
共 50 条
  • [1] Anti-infective Potential of Manzamine Alkaloids-A Review
    Ashok, Penta
    Faheem
    Kumar, Banoth K.
    Chander, Subhash
    Sekhar, Kondapalli Venkata Gowri Chandra
    Sankaranarayanan, Murugesan
    MEDICINAL CHEMISTRY, 2022, 18 (06) : 629 - 654
  • [2] Benzothiazole Derivatives as Potential Anti-Infective Agents
    Sharma, Prabodh Chander
    Bansal, Kushal Kumar
    Deep, Aakash
    Pathak, Meenakshi
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2017, 17 (02) : 208 - 237
  • [3] Anti-infective Agents
    Tomioka, Haruaki
    CURRENT PHARMACEUTICAL DESIGN, 2021, 27 (38) : 3947 - 3948
  • [4] Therapeutic drug monitoring of intracellular anti-infective agents
    D'Avolio, Antonio
    Pensi, Debora
    Baietto, Lorena
    Di Perri, Giovanni
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 101 : 183 - 193
  • [5] Natural and Synthetic Naphthoquinones as Potential Anti-Infective Agents
    Ortiz-Perez, Eyra
    Rivera, Gildardo
    Salas, Cristian O.
    Zarate-Ramos, Juan J.
    Trofymchuk, Oleksandra S.
    Hernandez-Soberanis, Lucio
    Perales-Flores, Juanita D.
    Vazquez, Karina
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2021, 21 (22) : 2046 - 2069
  • [6] Iminosugars and relatives as antiviral and potential anti-infective agents
    Greimel, P
    Spreitz, J
    Stütz, AE
    Wrodnigg, TM
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2003, 3 (05) : 513 - 523
  • [7] Anti-infective agents - Preface
    Chu, DTW
    CURRENT PHARMACEUTICAL DESIGN, 2001, 7 (05) : U6 - U6
  • [8] Anti-infective agents - Preface
    Chu, DTW
    CURRENT PHARMACEUTICAL DESIGN, 1999, 5 (07) : U2 - U2
  • [9] Anti-infective agents - Preface
    Chu, DTW
    CURRENT PHARMACEUTICAL DESIGN, 2000, 6 (02) : U2 - U2
  • [10] Oligosaccharide anti-infective agents
    Zopf, D
    Roth, S
    LANCET, 1996, 347 (9007): : 1017 - 1021
12345